鼻部小汗腺汗孔癌颈部转移1例  

Eccrine porocarcinoma of the nose with cervical metastasis:a case report

作　　者：李晨[1] 何时知 钟琦[2] LI Chen;HE Shizhi;ZHONG Qi

机构地区：[1]福建医科大学附属协和医院耳鼻咽喉科,福州350001 [2]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2020年第7期657-659,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：小汗腺汗孔癌(eccrine porocarcinoma,EPC)又称亲表皮性小汗腺癌、恶性小汗腺汗孔瘤,是一种起源于表皮内汗腺导管上皮的罕见恶性皮肤附属器肿瘤,于1963年由Pinkus与Mehregan首次报道,约占皮肤上皮肿瘤的0.005%。本病多发于60~80岁的老年患者,约20%可出现局部皮肤或淋巴结转移,少数出现远处转移[1]。EPC临床少见,发生于鼻部者罕见,现报告1例。An 18-year-old man presented with a slow-growing,painful mass on the nasal dorsum that first appeared 4 years earlier.Clinical examination revealed a 5 cm×6 cm,claret-coloured,firm,nonmobile mass on the dorsum of the nose with superficial ulceration and purulent discharge.After several operations,radiotherapy and chemotherapy,no nasal recurrence was found,but recurrence of metastatic masses in the neck.Histopathologic examination showed that the neoplasms were solid nests with adenoid and squamous differentiation.Immunohistochemical result showed that EMA(-),CEA(-),p16(+),p53(+),Ki-67 progressive heighten.The disease is rare,and clinical manifestations are nonspecific.Diagnosis depends on histopathological examination.Ki-67 can be used as a reference index to judge the degree of EPC malignancy.Expanded early excision should be performed.Patient with cervical metastasis had a poor prognosis.Radiotherapy and chemotherapy were ineffective.

关 键 词：小汗腺汗孔癌 淋巴结清扫术 

分 类 号：R739.62[医药卫生—肿瘤]