Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases:a role of mitochondria targeted catalase and xanthophylls  

作　　者：Mikhail A.Filippov Olga G.Tatarnikova Natalia V.Pozdnyakova Vasily V.Vorobyov 

机构地区：[1]Sistema-BioTech,LLC,Moscow,Russia [2]Institute of Cell Biophysics,Russian Academy of Sciences,Pushchino,Russia

出　　处：《Neural Regeneration Research》2021年第2期223-233,共11页中国神经再生研究（英文版）

摘　　要：Various inflammatory stimuli are able to modify or even"re-program"the mitochondrial metabolism that results in generation of reactive oxygen species.In noncommunicable chronic diseases such as atherosclerosis and other cardiovascular pathologies,type 2 diabetes and metabolic syndrome,these modifications become systemic and are characterized by chronic inflammation and,in particular,"neuroinflammation"in the central nervous system.The processes associated with chronic inflammation are frequently grouped into"vicious circles"which are able to stimulate each other constantly amplifying the pathological events.These circles are evidently observed in Alzheimer's disease,atherosclerosis,type 2 diabetes,metabolic syndrome and,possibly,other associated pathologies.Furthermore,chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer's disease.This is supposedly associated with some common genetic polymorphisms,for example,Apolipoprotein-Eε4 allele carriers with Alzheimer's disease can also develop atherosclerosis.Notably,in the transgenic mice expressing the recombinant mitochondria targeted catalase,that removes hydrogen peroxide from mitochondria,demonstrates the significant pathology amelioration and health improvements.In addition,the beneficial effects of some natural products from the xanthophyll family,astaxanthin and fucoxanthin,which are able to target the reactive oxygen species at cellular or mitochondrial membranes,have been demonstrated in both animal and human studies.We propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodegenerative disorders and other noncommunicable diseases associated with chronic inflammation in ageing.Furthermore,some prospective drugs based on mitochondria targeted catalase or xanthophylls could be used as an effective treatment of these pathologies,especially at early stages of their development.

关 键 词：algae xanthophylls Alzheimer's disease atherosclerosis depression type 2 diabetes metabolic syndrome mitochondria-targeted catalase noncommunicable chronic diseases stress 

分 类 号：R741.02[医药卫生—神经病学与精神病学]