Novel Galectin-3 interactions involved in oligodendroglial differentiation make inroads into therapeutic strategies for demyelinating diseases  

作　　者：Laura Andrea Pasquini 

机构地区：[1]Department of Biological Chemistry,School of Pharmacy and Biochemistry,Institute of Biological Chemistry and Physicochemistry(IQUIFIB),University of Buenos Aires and National Research Council(CONICET),Buenos Aires,Argentina

出　　处：《Neural Regeneration Research》2021年第2期289-290,共2页中国神经再生研究（英文版）

基　　金：grants from Agencia Nacional de Promoción Científica y Tecnológica(Argentina,PICT 2016-0319);Universidad de Buenos Aires(20920160100683BA,to LAP)。

摘　　要：Galectins(Gals)constitute a 15-member class ofβ-galactoside-binding lectins which recognize N-acetyllactosamine.Despite lacking specific receptors,Gals form multivalent complexes with cell surface glycoconjugates containing suitable oligosaccharides and thus trigger intracellular signals to regulate cell survival and differentiation.Gals are classified into three groups on the basis of their structural architecture:proto,chimera and tandem types。

关 键 词：SPITE COMPLEXES strategies 

分 类 号：R744.5[医药卫生—神经病学与精神病学]