抗N-甲基-D-天冬氨酸受体脑炎伴发视阵挛一例  

Ocular opsoclonus associated with anti-N-methyl-D-aspartate receptor encephalitis:a case report

作　　者：刘静[1] 樊春秋[1] 刘爱华[1] 杨冬菊[1] 陈芳[1] 韩建[1] Liu Jing;Fan Chunqiu;Liu Aihua;Yang Dongju;Chen Fang;Han Jian(Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院神经内科,北京100053

出　　处：《中华神经科杂志》2020年第8期611-613,共3页Chinese Journal of Neurology

摘　　要：视阵挛是临床上较为少见的扫视侵扰类型,是多方向的无规则的无间歇期的连续性快速眼球运动,导致眼球固视维持障碍类似"跳舞"。报道1例抗N-甲基-D-天冬氨酸受体脑炎患者所伴发的视阵挛体征。该患者于病程第5周病情达峰,在非惊厥持续状态基础上出现视阵挛现象,伴口角及四肢频繁不自主抽动。在抗癫痫、甲泼尼龙及丙种球蛋白冲击等积极治疗下,视阵挛现象至病程第7周逐渐缓解。国内关于此类眼征的报道不多,结合文献分析其可能的产生机制,以提高临床医师对该体征的认识。Ocular opsoclonus is a rare disorder of the saccadic system,in which fixation is continuously interrupted by involuntary,chaotic,rapid and multi-directional saccadic eye movements,interrupting the gaze-holding function,leading to“dancing eyes”.Ocular opsoclonus has rarely been reported in China.A case of ocular opsoclonus associated with anti-N-methyl-D-aspartate receptor encephalitis is reported to improve awareness about the ocular sign.The patient′s condition reached the peak at the 5th week.He developed ocular opsoclonus on the basis of nonconvulsive status epilepticus,accompanied by frequent involuntary movements of the mouth and limbs.The ocular opsoclonus gradually relieved on the 7th week with the active treatment.

关 键 词：视阵挛 受体 N-甲基-D-天冬氨酸 脑炎 扫视侵扰 眼震 

分 类 号：R742.9[医药卫生—神经病学与精神病学] R747.9[医药卫生—临床医学]