耐药性癫痫界定的再思考  

Reconsideration of the definition of drug resistant epilepsy

作　　者：于紫涵 余年[1] 狄晴[1] Yu Zihan;Yu Nian;Di Qing(Department of Neurology,Brain Hospital,Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院神经内科,210029

出　　处：《中华神经科杂志》2020年第8期636-640,共5页Chinese Journal of Neurology

摘　　要：2009年国际抗癫痫联盟发布了耐药性癫痫(DRE)的统一标准,通过治疗失败的AEDs数量、发作控制的标准、观察随访时间三个核心要素界定DRE。然而该标准在临床实际应用中仍存在问题,甚至尚有争议。文中从DRE定义的历史演变、核心要素、存在的问题对DRE的界定进行再思考,并提出部分DRE患者界定为慢性癫痫可能更恰当,以便为今后临床和科学研究提供参考。International League Against Epilepsy published a unified standard for drug resistant epilepsy by numbers of unsuccessful anti-epileptic drugs,criteria for seizure control and follow-up time in 2009.However,there are still some problems and even some controversies in the clinical application of this standard.To provide references for future clinical application and scientific research,we reconsider the definition of drug resistant epilepsy from its historical definitions,core elements and existing problems,and propose that some drug resistant epilepsy patients are probably more appropriately defined as chronic epilepsy.

关 键 词：癫痫 抗药性 生活质量 

分 类 号：R742.1[医药卫生—神经病学与精神病学]