碳糖苷类活性分子研究进展  

Progress of C-Glycosyl Molecules

作　　者：周新燃 蔡津津 解瑞 涂璇 黄年玉 ZHOU Xin-ran;CAI Jin-jin;XIE Rui;TU Xuan;HUANG Nian-yu(Key Laboratory of Natural Products Research and Development,College of Biological and Pharmaceutical Sciences,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学生物与制药学院,天然产物研究与利用湖北省重点实验室,湖北宜昌443002

出　　处：《化学试剂》2020年第8期940-947,共8页Chemical Reagents

基　　金：国家自然科学基金资助项目(21602123,21272136)。

摘　　要：碳糖苷因具有独特的生物活性而备受关注,但上市的碳糖苷类药物不多,为拓展碳糖苷分子的医药用途,加速其新药研发进程,有必要对其研发情况进行综述。通过查阅近十年文献,对碳糖苷活性分子的来源、获取途径、结构特点、作用机制和应用情况进行了分析整理,从降糖、抗肿瘤、心血管保护、抗菌和抗病毒活性等五方面进行了归纳总结,发现天然来源的糖苷类分子具有广泛生物活性,但其多靶点作用机制尚有待于深入研究。为碳糖苷分子的药物开发提供参考。The C-glycosides have attracted widely attention due to their unique biological activity,whereas few of them are marketed drugs.In order to explore the medical use of C-glycosides and accelerate their development of new drugs,it is necessary to review their research and development.The sources,acquiring approaches,structural features,biological mechanisms and applications of C-glycoside molecules were collected from the literatures reported on the domestic and foreign periodicals in the late decade.The research progress was summarized in five aspects from hypoglycemic,antitumor,cardiovascular protection,antibacterial and antiviral activities.Some natural C-glycosides were found to possess various activities,but their multi-target mechanisms remain to be further studied.A reference for the drug development of the C-glycosides was provided.

关 键 词：碳糖苷 糖衍生物 天然产物 药理活性 研究进展 

分 类 号：R914.4[医药卫生—药物化学]