帕金森病前驱期患者非运动症状研究  

Non-motor Symptoms in Prodromal Parkinson’s Disease

作　　者：任静茹 刘卫国[1] 华平[1] 陈勇[2] 张丽[3] 黄沛钰[4] 张敏鸣[4] 徐评议[5] REN Jing-ru;LIU Wei-guo;HUA Ping;CHEN Yong;ZHANG Li;HUANG Pei-yu;ZHANG Min-ming;XU Ping-yi(Department of Neurology,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Laboratory,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Geriatrics,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Radiology,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Neurology,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]南京医科大学附属脑科医院神经内科,南京210029 [2]南京医科大学附属脑科医院检验科,南京210029 [3]南京医科大学附属脑科医院老年医学科,南京210029 [4]浙江大学医学院附属第二医院放射科,杭州310009 [5]广州医科大学附属第一医院神经内科,广州510120

出　　处：《中国临床神经科学》2020年第3期266-272,共7页Chinese Journal of Clinical Neurosciences

基　　金：国家重点研发计划重点专项(编号:2016YFC1306600、2017YFC1310302);国家自然科学基金面上项目(编号:81571348);江苏省科技计划项目重点项目(编号:BE2019611);江苏省自然科学基金面上项目(编号:BK20151077)。

摘　　要：目的探讨帕金森病(PD)前驱期患者非运动症状特点。方法2017年3月至2018年12月于南京市社区筛查共纳入36例PD前驱期患者(PD前驱期组)和36例年龄、性别及受教育年限相匹配的健康老年人(对照组)。所有受试者均采用统一帕金森病评定量表第三部分(UPDRS-Ⅲ)、简易智能评估量表(MMSE)、蒙特利尔认知评估量表(Mo CA)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和非运动症状问卷筛查量表(NMS Quest)进行评估。结果筛查到的PD前驱期患者占总筛查人数的3.02%。PD前驱期组UPDRS-Ⅲ评分、HAMD评分、HAMA评分和NMS Quest评分高于对照组,MMSE评分和Mo CA评分低于对照组,均差异有统计学意义(P<0.05)。PD前驱期患者中100%至少出现一种非运动症状。PD前驱期组各非运动症状症候群发生率均高于对照组,差异有统计学意义(P<0.05)。结论PD前驱期患者非运动症状复杂多样,应重视社区中存在非运动症状人群并及时筛查。Aim To explore the characteristics of non-motor symptoms(NMS)in patients with prodromal Parkinson’s disease(PD).Methods From March 2017 to December 2018,36 prodromal PD patients and 36 healthy controls were recruited from Nanjing community by screening.All subjects were evaluated by Unified Parkinson’s Disease Rating Scale PartⅢ(UPDRS-Ⅲ),Mini-mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA)and Non-motor Questionnaire(NMS Quest).Results PD prodromal patients accounted for 3.02%of the total screening population.The scores of UPDRS-III,HAMD,HAMA and NMS Quest in prodromal PD patients were higher than those of healthy controls.The scores of MMSE,MoCA in prodromal PD patients were lower than those of the healthy controls(P<0.05).NMS were experienced by 100%of prodromal PD patients.The incidence of NMS domains in prodromal PD patients was higher than that in the healthy controls(P<0.05).Conclusion Patients with prodromal PD have complex and diverse NMS,so the population with NMS in the community should be paid attention and screened in time.

关 键 词：帕金森病 前驱期 非运动症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]