盐酸屈他维林的多晶型研究  

Polymorphs of Drotaverine hydrochloride

作　　者：应一锋 曾建华 叶云生 YING Yifeng;ZENG Jianhua;YE Yunsheng(Zhejiang Apeloa Kangyu Pharmaceutical Co.,Ltd.,Dongyang,Zhejiang,322118 P.R.China)

机构地区：[1]浙江普洛康裕制药有限公司,浙江东阳322118

出　　处：《华西药学杂志》2020年第4期365-367,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究盐酸屈他维林的晶型。方法建立了盐酸屈他维林晶型制备方法和分析方法,通过用水和乙醇重结晶得到盐酸屈他维林的Ⅰ、Ⅱ、Ⅲ晶型,并用粉末X-ray衍射法和差示扫描量热法分析对这些晶型进行表征。结果与结论晶型Ⅰ可能含0.5个乙醇分子,晶型Ⅱ、Ⅲ可能分别含1个、1.5个水分子。OBJECTIVE To study the crystal form of Drotaverine hydrochloride( DH). METHODS The methods for preparation and analysis of the polymorphs of DH were established. DH was recrystallized from water or ethanol,and three polymorphic forms which were defined as form I,form Ⅱ and form Ⅲ,were obtained and characterized by powder X-ray diffraction and differential scanning calorimetry. RESULTS and CONCLUSION Form I may contain 0. 5 ethanol molecules.Form II and Form III may contain 1 and 1. 5 water molecules respectively.

关 键 词：盐酸屈他维林 多晶型 结晶 粉末X-ray衍射法 差示量热扫描法 氢核磁共振谱 干燥失重 水分 

分 类 号：R914[医药卫生—药物化学]