血清游离轻链比值及治疗后比值正常化对初诊多发性骨髓瘤患者诊断及预后的影响  

Effect of Serum Free Light Chain Ratio and Normalization Ratio after Treatment on Diagnosis and Prognosis of Patients with Newly Diagnosed Multiple Myeloma

作　　者：李喆琪 田卫伟[1] 郭雅芳[1] 马梁明[1] LI Zhe-Qi;TIAN Wei-Wei;GUO Ya-Fang;MA Liang-Ming(Department of Hematology,Shanxi Bethune Hospital of Shanxi Medical University,Taiyuan 030032,Shanxi Province,China)

机构地区：[1]山西医科大学附属白求恩医院血液内科,山西太原030032

出　　处：《中国实验血液学杂志》2020年第4期1245-1250,共6页Journal of Experimental Hematology

基　　金：山西省科技成果转化引导专项项目(201604D131005);山西省重点研发项目(201603D321055)。

摘　　要：目的:评估血清游离轻链(serum free light chain,sFLC)κ/λ比值(sFLCR)对初诊多发性骨髓瘤(multiple myeloma,MM)的诊断及预后价值,并探讨4个疗程诱导治疗后sFLCR正常化对预后的影响。方法:回顾性分析2014年1月至2019年1月收治的43例初诊MM患者的临床资料,免疫比浊法检测sFLCκ/λ的表达水平,并以受累与非受累轻链比值100为界将患者分为高比率组(sFLCR≥100或≤0.01)和低比率组(0.010.05)。结论:初诊时sFLCR高比率组患者肾功能更差,疾病分期更晚治疗深度缓解率更低,疾病进展更早,生存期更短,临床预后更差。Objective:To evaluate the value of serum free light chain(sFLC)κ/λratio(sFLCR)on the diagnosis and prognosis of patients with newly diagnosed multiple myeloma(MM),and explore the effect of sFLCR normalization on the prognosis of patients after 4 courses of induction therapy.Methods:The clinical data of 43 newly diagnosed MM patients from January 2014 to January 2019 were analyzed retrospectively.Immunoturbidimetry was used to detect the expression levels of sFLCκandλ.According to the ratio of involved and uninvolved sFLC,using 100 as a boundary,the MM patients were divided into the high ratio group(sFLCR≥100 or≤0.01)and the low ratio group(0.010.05).Conclusion:Patients in the high ratio group at the initial diagnosis have worse renal function,later stage of disease,lower deep remission rate,earlier disease progression,shorter survival time,and worse clinical prognosis.

关 键 词：多发性骨髓瘤 血清游离轻链κ/λ比值 预后 

分 类 号：R733.3[医药卫生—肿瘤]