胃食管反流病与睡眠障碍相关性的临床研究  

Clinical Study of the Correlation between Gastroesophageal Reflux Disease and Sleep Disorders

作　　者：窦维佳 王新 胡博 周金池 李丽丽 程浩 王景杰 刘震雄 Dou Weijia;Wang Xin;Hu Bo(Department of Gastroenterology,Tangdu Hospital,Air Force Medical University(Fourth Military Medical University),Shaanxi 710038,China)

机构地区：[1]中国人民解放军空军军医大学(第四军医大学)唐都医院消化内科,西安710038 [2]陕西省渭南市澄城县人民医院,715200

出　　处：《医学研究杂志》2020年第8期154-157,共4页Journal of Medical Research

摘　　要：目的研究胃食管反流病(GERD)患者中睡眠障碍的发生情况,并探讨GERD相关症状特点与睡眠障碍的相互关系。方法选择2018年1~12月就诊于笔者医院的96例GERD患者和同期100例健康体检者作为调查对象,发放睡眠质量(匹兹堡睡眠质量指数量表)和反流性疾病调查问卷表,进行量化评分,对睡眠障碍与GERD症状的相关性进行评价,结果96例GERD组中睡眠障碍58例(60.4%)高于对照组,差异有统计学意义(P<0.05);内镜阳性组睡眠障碍发生率(75.9%)显著高于内镜阴性组(53.7%),差异有统计学意义(P<0.05);反流性食管炎不同严重程度患者的睡眠障碍发生率比较(A+B:68.2%;C+D:100%)差异无统计学意义(P>0.05)。有睡眠障碍GERD患者反酸、胃灼痛症状所占比例分别为79.3%(46/58)、77.6%(45/58),明显高于无睡眠障碍GERD患者(P<0.05),而有睡眠障碍GERD患者暧气、胸骨后疼痛症状所占比例为51.7%(30/58)及39.6%(23/58),与无睡眠障碍GERD患者比较,差异无统计学意义(P>0.05);有睡眠障碍GERD患者反酸、胃灼痛及RDQ总评分髙于无睡眠障碍GERD患者,差异有统计学意义(P<0.05)<结论GERD患者常合并睡眠障碍,其睡眠障碍与GERD患者反酸、胃灼痛症状密切相关,治疗时应采用联合治疗方案,以提高疗效。Objective To investigation the status of sleep disorder in patients with gastroesophageal reflux disease(GERD)and to explore relationship between symptom characteristics of GERDand sleep disorders.Methods 96 patients with GERD and 100 controls at our hospital from January 2018 to December 2018 filled in the questionnaire to obtain the scores of sleep quality(Pittsburgh sleep quality index,PSQD and reflux disease questionnaire(RDQ).The correlation between sleep disorder and GERD symptoms was evaluated by quantifying the score.Results Among 96 patients with GERD,58(60.4%)patients had sleep disorders,which was higher than that in control group.The difference was statistically significant(P<0.05).The incidence of sleep disorders in the endoscopic positive group(75.9%)was significantly higher than that in the endoscopic negative group(53.7%),with statistically significant difference(P<0.05).The incidence of sleep disorders in patients with reflux esophagitis of different severity(A+B:68.2%;C+D:100%)was not statistically significant(P>0.05).The proportion of acid regurgitation and heartburn in GERD patients with sleep disorders were 79.3%(46/58)and 77.6%(45/58),respectively,which were significantly higher than those of GERD patients without sleep disorders(P<0.05).The proportion of eructation and retrosternal pain in GERD patients with sleep disorders were 51.7%(30/58)and 39.6%(23/58),respectively,which were not statistically significant compared with GERD patients without sleep disorders(P>0.05).The scores of acid regurgitation and heartburn as well as the total scores of KDQ were higher in GERD patients with sleep disorders than those in GERD patients without sleep disorders.And the differences were statistically significant(P<0.05).Conclusion Sleep disorders often coexist in GERD patients and Sleep disorders are closely associated with the symptoms in patients with GERD.We should use combined treatment methods to improve therapeutic efficacy of GRED.

关 键 词：胃食管反流病 睡眠障碍 匹兹堡睡眠质量指数量表 反流性疾病问卷 

分 类 号：R57[医药卫生—消化系统]