SIRT家族在缺血性脑卒中中作用的研究进展  

Advances on the role of SIRT family in ischemic stroke

作　　者：河泰麟 庞涛 HE Tailin;PANG Tao(Institute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing 210009, China)

机构地区：[1]中国药科大学药物科学研究院,江苏南京210009

出　　处：《医学研究与教育》2020年第4期1-7,共7页Medical Research and Education

基　　金：中国药科大学“双一流”建设科技创新团队项目(CPU2018GY06)。

摘　　要：沉默调节蛋白(sirtuins,SIRT)家族是NAD^+依赖性赖氨酸去乙酰化酶和ADP核糖转移酶的进化保守家族,调节细胞生理活性。NAD^+水平在细胞生理活动中是动态变化的,NAD^+的异常变化会引起各种疾病。SIRT在大脑中具有细胞特异性及细胞器特异性表达,参与多种疾病的发生,如缺血性脑卒中。因此,开发和使用SIRT特异性调节剂可以促进神经保护,有望成为治疗缺血性脑卒中的新靶点。The SIRT family is an evolutionarily conserved family of NAD^+-dependent lysine deacetylases and ADP ribose transferases that regulate cell physiological activity.NAD^+levels are dynamically changed in the physiological activities of cells,whose abnormal changes can cause various diseases.SIRT has cell-specific and organelle-specific expressions in the brain and is involved in the pathology of many diseases,including ischemic stroke.Therefore,the development and use of SIRT-specific modulators might exhibit neuroprotection effects and is expected to develop a new target for the treatment of ischemic stroke.

关 键 词：缺血性脑卒中 沉默调节蛋白 NAD^+ 

分 类 号：R743.3[医药卫生—神经病学与精神病学]