微重力引起的骨质丢失研究进展  

Research progress of bone loss induced by simulated microgravity

作　　者：张世明 尹文哲[1] 陶天遵[1] 陶树清[1] 夏玉城 朱立宇 ZHANG Shiming;YIN Wenzhe;TAO Tianzun;TAO Shuqing;XIA Yucheng;ZHU Liyu(The Second Affiliated Hospital of Harbin Medical University, Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150001

出　　处：《中国骨质疏松杂志》2020年第8期1231-1234,共4页Chinese Journal of Osteoporosis

摘　　要：人类对太空的探索日益频繁,然而太空微重力会引起航天员骨质丢失,对航天员的健康造成损害。因此,有研究者通过航天实验及模拟微重力实验研究微重力下骨质丢失的发生机制及解决措施。微重力会引起成骨细胞和破骨细胞代谢活动改变,并引起机体对钙离子新陈代谢的改变。航天微重力导致的骨质丢失是微重力和太空射线共同作用的结果。本文将对微重力所致骨质丢失的发生机制和治疗对策加以概述。Human exploration of space is becoming more and more frequent.However,space microgravity will cause bone loss in astronauts,which will causes damage to the astronauts’health.Therefore,some researchers have studied the mechanism and solution of bone loss under microgravity through the aerospace experiments and the simulated microgravity experiments.Metabolisms of bone loss induced by simulated microgravity,osteoclasts and calcium ions are changed by microgravity.The bone loss caused by aerospace microgravity is the result of the combined action of microgravity and space rays.In this review,the mechanism and treatment of bone loss induced by simulated microgravity are summarized.

关 键 词：微重力 骨质丢失 成骨细胞 破骨细胞 对策 

分 类 号：R-1[医药卫生]