血清CYFRA21-1、TSGF、OPN在宫颈癌晚期中的表达及意义  

Analysis of the Expression and Significance of Serum CYFRA21-1,TSGF and OPN in Advanced Cervical Cancer

作　　者：苏玥辉[1] 张梦真[1] SU Yuehui;ZHANG Mengzhen(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2020年第8期1278-1280,共3页The Practical Journal of Cancer

摘　　要：目的探讨血清细胞角蛋白19片段抗原(CYFRA21-1)、恶性肿瘤特异生长因子(TSGF)、骨桥蛋白(OPN)在宫颈癌晚期中的表达及意义。方法选择45例女性宫颈癌晚期患者为研究对象,收集所有患者手术切除病理组织制作石蜡切片,并选择同期接受其他手术的40例标本作为对照组,应用双抗体夹心酶联免疫吸附法观察乳腺癌组织中CYFRA21-1、TSGF、OPN检测结果,并分析其与临床病理因素的关系。结果在酶联免疫吸附法结果中显示,观察组患者血清CYFRA21-1、TSGF、OPN水平均显著性高于对照组;在宫颈癌组织中CYFRA21-1、TSGF、OPN的表达水平与肿瘤分化程度、临床分期及淋巴结转移均有密切关系,将分化程度、临床分期及淋巴转移作为因变量,将血清CYFRA21-1、TSGF、OPN分别作为自变量,在相关性分析结果中显示,血清CYFRA21-1、TSGF、OPN与分化程度、临床分期及淋巴结转移均呈正相关。结论在宫颈癌晚期组织中CYFRA21-1、TSGF、OPN的高表达与临床病理之间存在着密切关系,可促使疾病进展,而本次研究也为靶向药物治疗宫颈癌提供了新思路。Objective To study Analysis of the Expression and significance of serum CYFRA21-1,TSGF and OPN in advanced cervical cancer.Methods 45 female late cervical cancer patients as the research object,collect all the surgical resection in patients with pathological tissue paraffin section,and select other surgery specimens of 40 cases as the control group at the same time,application of double antibody sandwich enzyme-linked immunosorbent method to observe breast cancer tissues,TSGF,OPN CYFRA21-1 test results,and analyzes its relationship with clinical pathological factors.Results The results of enzymatically linked immunosorbent assay showed that the serum levels of cyfra21-1,TSGF and OPN in the observation group were significantly higher than those in the control group.The expression levels of cyfra21-1,TSGF and OPN in cervical cancer tissues were closely related to the degree of tumor differentiation,clinical stage and lymph node metastasis.Differentiation degree,clinical stage and lymph node metastasis were taken as the dependent variables,and serum cyfra21-1,TSGF and OPN were respectively taken as independent variables.The correlation analysis results showed that serum cyfra21-1,TSGF and OPN were positively correlated with differentiation degree,clinical stage and lymph node metastasis.Conclusion There is a close relationship between the high expression of cyfra21-1,TSGF and OPN in advanced cervical cancer tissues and clinicopathology,which can promote the progression of the disease.This study also provides a new idea for targeted drug treatment of cervical cancer.

关 键 词：宫颈癌 细胞角蛋白19片段抗原 恶性肿瘤特异生长因子 骨桥蛋白 

分 类 号：R737.33[医药卫生—肿瘤]