GP化疗联用艾迪注射液治疗老年晚期非小细胞肺癌的疗效及对患者免疫功能和生活质量的影响  

Efficacy of GP Chemotherapy combined with Aidi Injection on Elderly Advanced Non-small Cell Lung Cancer and Its Effects on Immune Function and Quality of Life of Patients

作　　者：谭红梅[1] 谭春梅[1] 冯晓丽[1] 潘彬[1] TAN Hongmei;TAN Chunmei;FENG Xiaoli(The First Affiliated Hospital of Chengdu Medical College,Chengdu,610500)

机构地区：[1]成都医学院第一附属医院,610500

出　　处：《实用癌症杂志》2020年第8期1327-1330,1346,共5页The Practical Journal of Cancer

摘　　要：目的观察GP(吉西他滨+顺铂)化疗联用艾迪注射液治疗老年晚期非小细胞肺癌(NSCLC)的近期疗效及对患者细胞免疫及生存质量的影响。方法研究选取120例NSCLC患者,采用随机数字表法分成观察组、对照组,各60例。观察组采用GP化疗联合艾迪注射液治疗,对照组仅采用GP方案治疗。治疗2个疗程后,评价2组近期疗效,观察2组化疗不良反应情况,比较2组外周血T淋巴细胞(CD3+、CD4+、CD8+)和Treg细胞(CD4+CD25+Treg)水平,采用karnofsky评分及肺癌患者生存质量量表(FACT-L)评价生活质量。结果治疗后,2组近期疗效整体比较差异无统计学意义(P>0.05),但观察组疾病控制率(81.67%)要优于对照组的65.00%(P<0.05);观察组恶心呕吐、白细胞减少、血小板降低、贫血等不良反应分级均优于对照组(P<0.05)。观察组CD3+、CD4+显著高于对照组(P<0.05),CD8+、CD4+CD25+Treg显著低于对照组(P<0.05)。观察组karnofsky评分及FACT-L得分均显著高于对照组(P<0.05)。结论GP化疗方案联合艾迪注射液用于老年晚期NSCLC患者治疗,对控制病情进一步恶化有积极意义,同时能调节患者免疫功能、降低化疗不良反应,且有利于改善患者生活质量。Objective To observe the short-term efficacy of GP(gemcitabine+cisplatin)chemotherapy combined with Aidi injection in the treatment of elderly advanced non-small cell lung cancer(NSCLC)and its effects on cellular immunity and quality of life of patients.Methods 120 patients with NSCLC were enrolled for the study,and were divided into the observation group and the control group according to the random number table method,with 60 cases in each group.The observation group was given GP chemotherapy combined with Aidi injection,and the control group was only treated with GP regimen.After 2 courses of treatment,the short-term efficacy was evaluated in the 2 groups,and the adverse reactions of chemotherapy were observed in the 2 groups,and the levels of peripheral blood T lymphocytes(CD3+,CD4+,CD8+)and Treg cells(CD4+CD25+Treg)were compared between the 2 groups,and karnofsky score and quality of life scale of lung cancer patient(FACT-L)were used to assess the quality of life.Results After treatment,there was no significant difference in the overall short-term efficacy between the 2 groups(P>0.05),but the disease control rate in the observation group was better than that of the control group(81.67%vs 65.00%)(P<0.05).The adverse reactions grades of nausea and vomiting,leukopenia,thrombocytopenia and anemia in the observation group were better than those of the control group(P<0.05).The CD3+and CD4+in the observation group were significantly higher than those of the control group(P<0.05)while the CD8+and CD4+CD25+Treg were significantly lower than those of the control group(P<0.05).The karnofsky score and FACT-L score in the observation group were significantly higher than those of the control group(P<0.05).Conclusion GP chemotherapy combined with Aidi injection for elderly patients with advanced NSCLC has positive significance in controlling the further deterioration of the disease.It can also regulate the immune function of patients and reduce the adverse reactions of chemotherapy,and it is beneficial to improve the qual

关 键 词：非小细胞肺癌 吉西他滨 顺铂 艾迪注射液 T淋巴细胞 生活质量 

分 类 号：R734.2[医药卫生—肿瘤]