乳腺癌内乳前哨淋巴结99mTc硫胶体联合亚甲蓝示踪活检术246例临床分析  

Application of 99mTc Sulfur-colloid combined with Methylene Blue Tracer Biopsy in Breast Cancer

作　　者：孙邦旭 杜江 林晶 钟红 SUN Bangxu;DU Jiang;LIN Jing(Xinjiang Medical University,Urumqi,830011)

机构地区：[1]新疆医科大学第三临床医学院,830011

出　　处：《实用癌症杂志》2020年第8期1347-1350,共4页The Practical Journal of Cancer

基　　金：新疆维吾尔自治区科技计划项目(科技援疆计划)(编号:2018 E02068)。

摘　　要：目的探讨乳腺癌内乳前哨淋巴结用99mTc硫胶体联合亚甲蓝示踪活检术的效果。方法选取初步诊治的早期乳腺癌患者246例,均经穿刺病理证实为乳腺癌,每位患者术前均注射亚甲蓝及99mTc硫胶体双示踪剂寻找内乳区前哨淋巴结(IM-SLN)及腋窝前哨淋巴结,根据检出的IM-SLN个数,分析两种示踪方式在乳腺癌内乳前哨淋巴结活检术(IM-SLNB)中的应用效果。结果246例患者中亚甲蓝示踪的IM-SLN成功率17.5%(43/246),腋窝前哨淋巴结成功率为100%(246/246)。99mTc硫胶体示踪的IM-SLN成功率为75.2%(185/246),腋窝前哨淋巴结成功率为100%(246/246)。亚甲蓝及99mTc硫胶体双重示踪的IM-SLN成功率为17.5%(43/246),腋窝前哨淋巴结100%(246/246)。在内乳区99mTc硫胶体示踪成功率明显高于亚甲蓝,差异具有统计学意义(P<0.05)。结论采用99mTc硫胶体示踪进行乳腺癌IM-SLNB成功率高,而亚甲蓝示踪IM-SLN成功率低,两者联合未增加内乳区IM-SLN检出率,而对腋窝前哨淋巴结两者成功率均高,亚甲蓝示踪IM-SLN不是一种理想的示踪剂。Objective To investigate the effect of 99mTc thiocolloid combined with methylene blue tracer biopsy in breast mammary sentinel lymph nodes.Methods 246 patients with early breast cancer who were initially diagnosed and treated were confirmed to have breast cancer by puncture pathology.Each patient was injected with methylene blue and 99mTc thiocolloid dual tracer before operation to look for sentinel lymph nodes in the internal breast area and axillary sentinel nodes Based on the number of IM-SLNs detected,the effect of the two tracing methods in breast mammary sentinel lymph node biopsy(IM-SLNB)was analyzed.Results The success rate of IM-SLN tracing of methylene blue in 246 patients was 17.5%(43/246),and the success rate of axillary sentinel lymph node was 100%(246/246).The success rate of IM-SLN with 99mTc sulfur colloidal tracing was 75.2%(185/246),and the success rate of axillary sentinel lymph node was 100%(246/246).The success rate of IM-SLN dual tracking of methylene blue and 99mTc sulfur colloid was 17.5%(43/246),and the axillary sentinel lymph node was 100%(246/246).The success rate of 99mTc sulfur colloidal tracing in the inner breast area was significantly higher than that of methylene blue,the difference was statistically significant(P<0.05).Conclusion The success rate of IM-SLNB for breast cancer using 99mTc sulfur colloidal tracing is high,while the success rate of IM-SLN for methylene blue tracing is low.The combination of the 2 do not increase the detection rate of IM-SLN in the internal breast area.Both have high success rates,and the methylene blue tracer IM-SLN is not an ideal tracer.

关 键 词：99mTc硫胶体 亚甲蓝 乳腺癌前哨淋巴结活检术 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]