CA724、CA153、PSA、HCG在肺癌患者病理类型诊断、临床分期及预后评估中的应用分析  

Application of CA724,CA153,PSA and HCG in the pathological type diagnosis,clinical staging and prognosis evaluation of patients with lung cancer

作　　者：刘小甲[1] 章文光 姚杰[2] 刘旭春[1] LIU Xiao-jia;ZHANG Wen-guang;YAO Jie;LIU Xu-chun(Department of General Medicine;Department of Cardiothoracic Surgery,Chizhou People's Hospital,Chizhou,Anhui 247000,China)

机构地区：[1]池州市人民医院全科医学科,安徽池州247000 [2]池州市人民医院胸心外科,安徽池州247000

出　　处：《临床肺科杂志》2020年第9期1405-1410,共6页Journal of Clinical Pulmonary Medicine

摘　　要：目的分析糖类抗原724(CA724)、糖类抗原153(CA153)、前列腺特异抗原(PSA)、人类绒毛膜促性腺激素(HCG)在肺癌患者病理类型诊断、临床分期及预后评估中的应用价值。方法回顾性分析本院2017年1月~2019年8月收治的72例非小细胞肺癌(NSCLC)患者血CA724、CA153、PSA、HCG水平,比较不同病理类型、临床分期、预后的患者血CA724、CA153、PSA、HCG水平,分析其在病理类型诊断、临床分期及预后评估中的应用。结果①肺腺癌患者CA724、CA153、PSA、HCG水平显著高于肺鳞癌患者(P<0.05);PSA诊断肺癌病理类型的曲线下面积(AUC)值最高,敏感度、特异度为84.37%、85.00%;②Ⅲ期、Ⅳ期患者CA724、CA153、PSA、HCG水平显著高于Ⅰ期、Ⅱ期患者,CA724、PSA与肺癌临床分期显著正相关(P<0.05);③复发转移组CA724、CA153、PSA、HCG水平显著高于未复发转移组(P<0.05),HCG预测肺癌预后的AUC值最高,敏感度、特异度为65.62%、70.00%;且CA724>14.12U/mL、HCG>96.64ng/L的肺癌患者累积无复发转移生存率分别显著低于CA724≤14.12U/mL、HCG≤96.64ng/L患者(P<0.05)。结论CA724、CA153、PSA、HCG用于肺癌病理类型诊断、临床分期及预后评估均有一定临床价值,值得临床重视。Objective To analyze the application value of carbohydrate antigen 724(CA724),carbohydrate antigen 153(CA153),prostate specific antigen(PSA)and human chorionic gonadotropin(HCG)in the pathological type diagnosis,clinical staging and prognosis evaluation of patients with lung cancer.Methods The levels of serum CA724,CA153,PSA and HCG levels in 72 patients with non-small cell lung cancer(NSCLC)from January 2017 to August 2019 were retrospectively analyzed,and they were compared among patients with different pathological types,clinical stages and prognosis.The application of above indexes in pathological type diagnosis,clinical staging and prognosis evaluation was analyzed.Results①The levels of CA724,CA153,PSA and HCG were significantly higher in patients with lung adenocarcinoma than those with lung squamous cell carcinoma(P<0.05).The area under the curve(AUC)of PSA for diagnosing the pathological type of lung cancer was the largest,and the sensitivity and specificity were 84.37%and 85.00%,respectively.②The levels of CA724,CA153,PSA and HCG at stageⅢandⅣwere significantly higher than those at stage I andⅡ.CA724 and PSA were significantly positively correlated with the clinical stage of lung cancer(P<0.05).③The levels of CA724,CA153,PSA and HCG were significantly higher in the recurrence and metastasis group than the non-recurrent and metastasis group(P<0.05).The AUC of HCG for predicting the prognosis of lung cancer was the largest,and the sensitivity and specificity were 65.62%and 70.00%,respectively.The cumulative recurrence-free metastasis-free survival rates of lung cancer patients with CA724>14.12U/mL and HCG>96.64ng/L were significantly lower than those with CA724≤14.12U/mL and HCG≤96.64ng/L(P<0.05).Conclusion CA724,CA153,PSA and HCG can be used for pathological type diagnosis,clinical staging and prognosis evaluation of lung cancer.

关 键 词：糖类抗原724 糖类抗原153 前列腺特异抗原 人类绒毛膜促性腺激素 肺癌 病理类型 临床分期 预后 

分 类 号：R734.2[医药卫生—肿瘤]