细胞因子白细胞介素-17A在鼻咽癌组织中的表达情况及临床意义  

Expression and clinical significance of the cytokine interleukin-17A in nasopharyngeal carcinoma

作　　者：吴烜[1,2,3] 童刚领 程勃然[1,2,3] 余少康 靳枫 王树滨[1,2,3] WU Xuan;TONG Gangling;CHENG Boran;YU Shaokang;JIN Feng;WANG Shubin(Department of Medical Oncology,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong,China;Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research,Shenzhen 518036,Guangdong,China;Cancer Institute,Shenzhen-PKU-HKUST Medical Center,Shenzhen 518036,Guangdong,China)

机构地区：[1]北京大学深圳医院肿瘤内科,广东深圳518036 [2]深圳市胃肠肿瘤转化研究重点实验室,广东深圳518036 [3]深圳北京大学香港科技大学肿瘤研究所,广东深圳5180360

出　　处：《癌症进展》2020年第15期1529-1532,1608,共5页Oncology Progress

基　　金：广东省自然科学基金博士启动项目(2016A030310242);深圳市科技创新委员会项目(JCYJ20150403091443271、GJHZ20180420180754917、ZDSYS20190902092855097);深圳市政府三名工程项目(SZSM201612041)。

摘　　要：目的探讨白细胞介素-17A(IL-17A)在鼻咽癌组织中的表达情况及临床意义。方法收集90例鼻咽癌患者的鼻咽癌组织和癌旁组织,采用免疫组织化学染色法检测鼻咽癌组织和癌旁组织中IL-17A、程序性死亡受体配体l(PD-L1)的表达情况,分析不同临床特征鼻咽癌患者鼻咽癌组织中IL-17A的表达情况,以及鼻咽癌组织中IL-17A与PD-L1表达的相关性,分析IL-17 A阳性和阴性患者的总生存情况和无进展生存情况。结果鼻咽癌组织中IL-17A的阳性表达率为62.22%(56/90),高于癌旁组织的12.22%(11/90),差异有统计学意义(P<0.05)。不同临床分期、组织分化程度、T分期、N分期、EB病毒(EBV)阳性情况鼻咽癌患者鼻咽癌组织中IL-17A的阳性表达率比较,差异均有统计学意义(P<0.05)。PD-L1阳性患者的IL-17A阳性表达率明显高于PD-L1阴性患者(P<0.01)。IL-17A阳性患者的中位生存期和中位无进展生存期均短于IL-17A阴性患者(P<0.05)。结论IL-17A在鼻咽癌组织中的阳性表达率较高,其表达情况与EBV感染、PD-L1表达情况、临床分期、组织分化程度及预后有关,IL-17A可能通过影响宿主免疫或肿瘤微环境参与鼻咽癌的免疫逃逸,导致肿瘤进展。Objective To explore the expression and clinical significance of interleukin-17 A(IL-17 A) in nasopharyngeal carcinoma.Method A total of 90 patients who had been diagnosed with nasopharyngeal carcinoma were included in the analysis,from whom the nasopharyngeal carcinoma tissues and adjacent normal tissues were collected,the expression of IL-17 A and programmed cell death 1 ligand 1(PD-L1) in nasopharyngeal carcinoma tissues and adjacent normal tissues were detected by immunohistochemistry.The expression of IL-17 A in patients with different clinical characteristics was analyzed,and the relationship between IL-17 A and PD-L1 expression was also analyzed.The overall survival(OS) and progression-free survival(PFS) of patients with positive and negative IL-17 A was investigated.Result The positive expression rate of IL-17 A in nasopharyngeal carcinoma tissues was 62.22%(56/90),and it was much higher than the 12.22%(11/90) observed in adjacent normal tissues(P<0.05).The positive expression rate of IL-17 A in nasopharyngeal carcinoma tissues was related to clinical stage,histological differentiation,T stage,N stage and Epstein-Barr virus(EBV) infection(P<0.05).The positive rate of IL-17 A in patients with positive PD-L1 expression was significantly higher than that in patients with negative PD-L1 expression(P<0.01).The median OS and median PFS of IL-17 A positive patients were significantly shorter than that of IL-17 A negative ones(P<0.05).Conclusion IL-17 A has a high positive expression rate in nasopharyngeal carcinoma tissues,with the expression being related to EBV infection,PD-L1 expression,clinical stage,degree of differentiation and prognosis,IL-17 A may affect host immunity or tumor microenvironment,and participate in immune escape of nasopharyngeal carcinoma and thus causes tumor progression.

关 键 词：鼻咽癌 白细胞介素-17A 程序性死亡受体配体1 EB病毒 免疫组织化学染色 

分 类 号：R739.62[医药卫生—肿瘤]