痰热清注射液联合抗生素治疗肺癌化疗后并发肺部感染患者的临床疗效  

Clinical effect of Tanreqing injection combined with antibiotics in the treatment of patients with lung infection after lung cancer chemotherapy

作　　者：杨艳芳[1] 郝艳艳 王金磊[1] 赵宝利[1] YANG Yanfang;HAO Yanyan;WANG Jinlei;ZHAO Baoli(Department of Critical Care Medicine,People’s Hospital of Jiyuan,Jiyuan 454650,He’nan,China)

机构地区：[1]济源市人民医院重症医学科,河南济源4546500

出　　处：《癌症进展》2020年第15期1593-1596,共4页Oncology Progress

摘　　要：目的探讨痰热清注射液联合抗生素治疗肺癌化疗后并发肺部感染患者的临床疗效。方法根据随机数字表法将127例肺癌化疗后并发肺部感染患者分为观察组(n=64)和对照组(n=63),两组患者均根据药敏实验采用敏感抗生素治疗,观察组患者同时给予痰热清注射液治疗。比较两组患者治疗前后的血清白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)、降钙素原(PCT)、C反应蛋白(CRP)、外周血白细胞(WBC)计数、氧合指数(PaO2/FiO2)及临床肺部感染评分(CPIS),比较两组患者治疗后的临床症状缓解时间及临床疗效。结果治疗前,两组患者的血清IL-1β、IL-8、PCT、CRP水平及外周血WBC计数和PaO2/FiO2比较,差异均无统计学意义(P>0.05);治疗5天后,观察组患者的血清IL-1β、IL-8、PCT、CRP水平及外周血WBC计数均低于对照组,PaO2/FiO2高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者的CPIS评分比较,差异无统计学意义(P>0.05);治疗5天后,观察组患者的CPIS评分明显低于对照组,差异有统计学意义(P<0.01)。治疗后,观察组患者的发热消失时间、肺部啰音消失时间、咳嗽咳痰消失时间均明显短于对照组,差异均有统计学意义(P<0.01)。治疗后,观察组患者的临床疗效优于对照组,差异有统计学意义(P<0.05)。结论对于肺癌化疗后并发肺部感染患者,痰热清注射液联合抗生素治疗能够有效缓解患者的临床症状,减轻炎性反应,提高临床治疗效果。Objective To explore the effect of Tanreqing injection combined with antibiotics in the treatment of patients with lung infection after lung cancer chemotherapy.Method A total of 127 patients with lung infection after lung cancer chemotherapy were included in the analysis as study group(n=64) and control group(n=63) according to a random number table,both groups of patients were treated with sensitive antibiotics as determined by drug sensitivity test,patients in the study group were given Tanreqing injection concomitantly.The serum interleukin-1β(IL-1β),interleukin-8(IL-8),procalcitonin(PCT) and C reactive protein(CRP),peripheral white blood cell(WBC) count,oxygenation index(PaO2/FiO2),clinical pulmonary infection score(CPIS) were compared between the two groups before and after treatment,besides,the time to recovery of clinical symptoms and clinical efncacy after treatment were compared between the wo groups.Result Before treatment,there was no statistically significant difference of IL-1β,IL-8,PCT,CRP,WBC and PaO2/FiO2 between the two groups(P>0.05);after 5 days of treatment,the IL-1β,IL-8,PCT,CRP,WBC were significantly lower and PaO2/FiO2 was significantly higher in study group compared to control group(P<0.05).Before treatment,there was no statistically significant difference of CPIS between the two groups(P>0.05);after 5 days of treatment,the CPIS was significantly lower in study group compared to control group(P<0.01).After treatment,the time to disappearance of fever and absence of lung rales as well as cough and expectoration were shorter compared to control group(P<0.01);after treatment,the clinical efncacy in study group was notably better than that in the control group(P<0.05).Conclusion For lung cancer patients with lung infection after chemotherapy,Tanreqing injection combined with antibiotics can effectively relieve the clinical symptoms,reduce the degree of inflammatory response,and augment the clinical efncacy.

关 键 词：痰热清注射液 肺癌 化疗 肺部感染 

分 类 号：R734.2[医药卫生—肿瘤]