胃癌根治术预后相关因素的研究  

The value of T-cadherin expression in predicting the prognosis of gastric cancer after radical operation

作　　者：李立新[1] 蔡翠芳[2] 李文祥 石磊[3] 蒲竞[3] LI Lixin;CAI Cuifang;LI Wenxiang;SHI Lei;PU Jing(Department of Oncology,Second People's Hospital of Lanzhou,Lanzhou,Gansu,China,730046;Department of Neurourology,Second People's Hospital of Lanzhou,Lanzhou,Gansu,China,730046;Department of General Surgery,Lanzhou Second People's Hospital,Lanzhou,Gansu,China,730046)

机构地区：[1]兰州市第二人民医院肿瘤外科,甘肃兰州730046 [2]兰州市第二人民医院神经泌尿外科,甘肃兰州730046 [3]兰州市第二人民医院普外科,甘肃兰州730046

出　　处：《分子诊断与治疗杂志》2020年第8期1001-1004,共4页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金面上项目(81970542)。

摘　　要：目的研究T-cadherin分子表达对胃癌根治术后预后的预测价值。方法选取2016年1月至2017年1月期间本院收治的198例胃癌患者为对象,根据术后临床情况分为预后良好组及预后不良组,分析患者临床疗效,采用多因素Logistic回归分析法分析胃癌根治术后预后不良的独立影响因素。结果198例胃癌患者中,有67(33.84%)例预后不良,131(66.16%)例预后良好。单因素分析结果显示,胃癌根治术后预后不良与肿瘤大小、Borrmann分型、T-cadherin表达有明显相关性,肿瘤大小>5 cm、Borrmann分型Ⅰ~Ⅱ型、T-cadherin表达<50%患者预后更差(P<0.05)。多因素Logistic回归分析显示,肿瘤大小、Borrmann分型、T-cadherin表达是胃癌根治术后预后不良的独立危险因素(P<0.05)。结论肿瘤大小>5 cm、Borrmann分型Ⅰ~Ⅱ、T-cadherin表达≤50.00%是胃癌根治术后不良预后的危险因素,需引起临床重视。Objective To investigate the prognostic value of T-cadherin expression in patients with gastric cancer after radical operation.Method 198 patients with gastric cancer admitted to our hospital from January 2016 to January 2017 were selected as the objects.According to the prognosis,they were divided into two groups:the group with good prognosis and the group with poor prognosis.The general data of the patients were collected,and the prognosis of the patients after radical gastrectomy was analyzed.The independent influencing factors of poor prognosis were analyzed by multivariate logistic regression analysis.Result Among198 patients with gastric cancer,67 had a poor prognosis,accounting for 33.84%.131 cases had a good prognosis,accounting for 66.16%.The results of univariate analysis showed that the poor prognosis after radical gastric cancer was significantly correlated with tumor size,Borrmann classification,and T-cadherin expression.Tumor size was greater than 5 cm,Borrmann classification I to II,and T-cadherin expression<50%of patients,the prognosis is worse(P<0.05).Multivariate logistic regression analysis showed that tumor size,Borrmann classification,T-cadherin expression is an independent risk factor for poor prognosis after radical gastric cancer(P<0.05).Conclusion Tumor size>5 cm,Borrmann typeⅠ~Ⅱand T-cadherin expression≤50.00%arer risk factors of poor prognosis after radical gastrectomy,which requires clinical attention.

关 键 词：T-cadherin分子 胃癌根治术 预后 BORRMANN分型 

分 类 号：R735.2[医药卫生—肿瘤]