星形细胞肿瘤组织EGFR、VEGF表达及其与病理分级的相关性研究  

Expression of EGFR and VEGF in astrocyte tumor tissues and their correlation with pathological grade

作　　者：张弛[1] 袁健[1] 彭刚[1] 谢源阳[1] 苏军 刘庆[1] 袁贤瑞[1] 李昊昱[1] ZHANG Chi;YUAN Jian;PENG Gang;XIE Yuanyang;SU Jun;LIU Qing;YUAN Xianrui;LI Haoyu(Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan,China,410008)

机构地区：[1]中南大学湘雅医院神经外科,湖南长沙410008

出　　处：《分子诊断与治疗杂志》2020年第8期1086-1089,共4页Journal of Molecular Diagnostics and Therapy

基　　金：中南大学湘雅医院青年科研基金(2019Q15)。

摘　　要：目的探讨星形细胞肿瘤组织中上皮生长因子受体(EGFR)、血管内皮生长因子(VEGF)表达及其与病理分级的相关性研究。方法选取本院2014年1月至2015年1月收治的98例星形细胞肿瘤患者及50例正常脑组织标本为对照组,利用免疫组织化学染色法对手术切除的癌组织、癌旁正常组织及正常脑组织中EGFR、VEGF表达水平进行检测,并分析EGFR、VEGF蛋白表达水平与患者临床病理分级的相关性。结果EGFR、VEGF蛋白在星形细胞肿瘤组织中的阳性表达率及表达水平均明显高于癌旁正常组织和正常脑组织(P<0.05),癌旁正常组织和正常脑组织中EGFR、VEGF蛋白阳性表达率无统计学差异(P>0.05);EGFR、VEGF蛋白的表达水平与星形细胞肿瘤患者的恶性程度、肿瘤大小、肿瘤分级、浸润程度相关(P<0.05);肿瘤组织中EGFR与VEGF表达呈正相关(r=0.859,P<0.05)。结论星形细胞肿瘤患者肿瘤组织中EGFR、VEGF蛋白水平高表达可能促进患者的病程发展。Objective To explore the expression of epidermal growth factor receptor(EGFR)and vascular endothelial growth factor(VEGF)in astrocyte tumor tissues and their correlation with pathological grade.Methods A total of 98 patients with astrocyte tumors who were admitted to the hospital from January2014 to January 2015 and 50 normal brain tissue specimens(the control group)were enrolled.The expression levels of EGFR and VEGF in cancer tissues of surgical excision,adjacent normal tissues and normal brain tissues were detected by immunohistochemical staining.The correlation between expression levels of EGFR and VEGF proteins and clinical pathological grades was analyzed.Results The positive expression rates and expression levels of EGFR and VEGF proteins in the astrocyte tumor tissues were significantly higher than those in the adjacent normal tissues and the normal brain tissues(P<0.05).There were no significant differences in positive expression rates of EGFR and VEGF proteins between the adjacent normal tissues and normal brain tissues(P>0.05).The expression levels of EGFR and VEGF proteins are correlated with the malignancy,tumor size,tumor grade and degree of invasion of astrocytic tumor patients(P<0.05).There was a positive correlation between EGFR and VEGF expression in tumor tissues(r=0.859,P<0.05).Conclusion The high expression of EGFR and VEGF proteins in tumor tissues of patients with astrocyte tumor may promote the progression of the disease course.

关 键 词：星形细胞肿瘤 上皮生长因子受体 血管内皮生长因子 

分 类 号：R739.4[医药卫生—肿瘤]