加巴喷丁联合尼莫地平对偏头痛发作期患者的血流动力学状态及PKC的影响  

Effects of gabapentin combined with nimodipine on hemodynamics and protein kinase C in migraine attack

作　　者：郜锦英 胡静 GAO Jin-ying;HU Jing(Department of Neurology,Ankang People's Hospital,Ankang 725000,Shaanxi,CHINA)

机构地区：[1]安康市人民医院神经内科,陕西安康725000

出　　处：《海南医学》2020年第16期2056-2058,共3页Hainan Medical Journal

摘　　要：目的探讨加巴喷丁联合尼莫地平对偏头痛发作期患者血流动力学状态及蛋白激酶C(PKC)的影响。方法选择安康市人民医院神经内科2017年6月至2018年8月收治的100例偏头痛发作期患者进行研究,根据随机数表法将患者均分为对照组和观察组,每组50例。对照组采用尼莫地平治疗,观察组采用加巴喷丁联合尼莫地平治疗,12 d为一个疗程。比较两组患者治疗前后的血流动力学状态和PKC水平,以及两组患者治疗后的疼痛评分(VAS)和不良反应情况。结果治疗前,观察组患者的左侧大脑中动脉(LMCA)、右侧大脑前动脉(RACA)、左大脑前动脉(LACA)、右大脑后动脉(RPCA)、左大脑后动脉(LPCA)、右侧大脑中动脉(RMCA)的平均血流速度与对照组比较差异均无统计学意义(P>0.05);治疗后,观察组患者的LMCA、RACA、LACA、RPCA、LPCA和RMCA的平均血流速度明显低于对照组,差异均有统计学意义(P<0.05);治疗前,两组患者的血浆PKC水平比较差异无统计学意义(P>0.05);治疗后,观察组患者的血浆PKC水平为(43.54±8.56)mL,明显低于对照组的(51.29±9.57)mL,差异有统计学意义(P<0.05);观察组患者治疗后的VAS评分为(0.51±0.13)分,明显低于对照组的(2.25±0.16)分,差异有统计学意义(P<0.05);观察组患者治疗后的不良反应发生率为4.0%,明显低于对照组的16.0%,差异具有统计学意义(P<0.05)。结论加巴喷丁联合尼莫地平治疗偏头痛发作期患者能够明显降低患者的PKC水平,改善血流动力学状态,有效缓解偏头痛。Objective To investigate the effect of gabapentin combined with nimodipine on hemodynamics and protein kinase C(PKC)in patients with migraine attack.Methods A total of 100 patients with migraine attack in Department of Neurology,Ankang People's Hospital from June 2017 to August 2018 were selected and randomly divided into control group and observation group,with 50 patients in each group.The control group was treated with nimodipine,and the observation group was treated with gabapentin combined with nimodipine,with 12 days as a course of treatment.The hemodynamic status and PKC level before and after treatment,as well as the pain score(VAS score)and adverse reactions were compared between the two groups.Results Before treatment,the average blood flow velocity of left middle cerebral artery(LMCA),right anterior cerebral artery(RACA),left anterior cerebral artery(LACA),right posterior cerebral artery(RPCA),left posterior cerebral artery(LPCA),and right middle cerebral artery(RMCA)in the observation group had no significant difference compared with those in the control group(P>0.05);after treatment,the average blood flow velocity of LMCA,RACA,LACA,RPCA,LPCA,and RMCA in the observation group was significantly lower than those in the control group(P<0.05).Before treatment,there was no significant difference in plasma PKC level between the two groups(P>0.05);after treatment,the plasma PKC level of the observation group was(43.54±8.56)mL,which was significantly lower than(51.29±9.57)mL of the control group(P<0.05).The VAS score of the observation group after treatment was(0.51±0.13)points,which was significantly lower than(2.25±0.16)points of the control group(P<0.05).The incidence of adverse reactions after treatment in the observation group was 4.0%,which was significantly lower than 16.0%of the control group(P<0.05).Conclusion Gabapentin combined with nimodipine in the treatment of migraine attack can significantly reduce the level of PKC,improve the hemodynamic status,and effectively relieve migraine.

关 键 词：偏头痛 发作期 加巴喷丁 尼莫地平 血流动力学 蛋白激酶C 

分 类 号：R747.2[医药卫生—神经病学与精神病学]