血细胞计数预测骨髓增殖性肿瘤患者血栓形成的意义  

The significance of WBC,PLT and hemoglobin counts in predicting thrombosis in patients with myeloproliterative neoplasms

作　　者：马强[1] MA Qiang(The First People's Hospital of Yinchuan,Yinchuan 750001,China)

机构地区：[1]宁夏银川市第一人民医院血液内科,宁夏银川750001

出　　处：《宁夏医学杂志》2020年第8期735-738,共4页Ningxia Medical Journal

摘　　要：目的研究外周血白细胞(WBC)计数、血小板(PLT)计数、血红蛋白(Hb)预测骨髓增殖性肿瘤(MPN)患者血栓形成的意义。方法纳入105例MPN患者为研究对象,统计一般资料,分析MPN患者血栓形成发生状况,并探讨外周血WBC计数、PLT计数、Hb对患者血栓形成的预测价值。结果105例患者中54例(51.43%)发生血栓事件,其中动脉血栓占38.10%,静脉血栓占7.62%,动静脉血栓占5.71%。年龄≥60岁(OR=3.992,95%CI=1.538~10.362)、高血压病史(OR=3.250,95%CI=2.320~4.553)、既往脑卒中病史(OR=4.302,95%CI=1.017~18.198)、既往血栓病史(OR=5.207,95%CI=1.070~25.339)、JAK2/V617F基因突变(OR=4.291,95%CI=1.549~11.887)、WBC≥15×10^9/L(OR=1.228,95%CI=1.065~1.416)、PLT≥450×10^9/L(OR=4.557,95%CI=1.378~15.070)、Hb≥170.00 g/L(OR=3.751,95%CI=1.540~9.136)是MPN患者血栓形成的独立影响因素(P<0.05)。WBC计数、PLT计数、Hb对MPN患者血栓形成均有一定预测价值,曲线下面积分别为0.708、0.678、0.656;WBC计数、PLT计数、Hb联合预测MPN患者血栓形成的曲线下面积为0.956。结论外周血WBC计数、PLT计数、Hb对MPN患者血栓形成具有重要的预测价值。Objective To study the significance of peripheral blood leukocyte count(WBC),platelet count(PLT)and hemoglobin(Hb)in predicting thrombosis in patients with myeloproliterative neoplasms(MPN).Methods 105 cases of MPN patients were selected.The general data of patients were collected to analyze the occurrence status of thrombosis in MPN patients.Multivariate Logistic regression analysis was used to analyze the independent influencing factors of thrombosis in MPN patients,and to explore the predictive value of peripheral blood WBC count,PLT count and Hb in patients with thrombosis.Results Among 105 patients,54(51.43%)had thrombotic events,including the arterial thrombosis(38.10%),venous thrombosis(7.62%)and arteriovenous thrombosis(5.71%).Multivariate logistic regression analysis showed that 60≥years(OR=1.252,95%CI=1.038~1.510),history of hypertension(OR=3.250,95%CI=2.320~4.553),history of stroke(OR=4.302,95%CI=1.017~18.198),history of thrombosis(OR=5.207,95%CI=1.070~25.339),JAK2/V617 gene mutation(OR=4.291,95%CI=1.549~11.887),WBC≥15×10^9/L(OR=1.228,95%CI=1.065~1.416),PLT≥450×10^9/L(OR=4.557,95%CI=1.378~15.070),Hb≥170.00 g/L(OR=3.751,95%CI=1.540~9.136)were also independent influencing factors of thrombosis in MPN patients(P<0.05).WBC count,PLT count and Hb had certain predictive value for thrombosis in MPN patients,and the area under the curve was 0.708,0.678 and 0.656,respectivel.The area under the curve of WBC count,PLT count and Hb combined to predict thrombosis in MPN patients was 0.956.Conclusion WBC count,PLT count and Hb in peripheral blood have important predictive value for thrombosis in MPN patients.

关 键 词：白细胞计数 血小板计数 血红蛋白 骨髓增殖性肿瘤 血栓 

分 类 号：R733.4[医药卫生—肿瘤]