感染SARS的医务人员抑郁情绪发生率及危险因素的系统评价  

Prevalence rate and related risk factors of depression among medical staff infected with SARS:a systematic review

作　　者：苏亮[1,2] 刘璨璨[2] 蔡亦蕴 徐逸[2] 徐一峰[2] Su Liang;Liu Cancan;Cai Yiyun;Xu Yi;Xu Yifeng(Huashan Hospital,Fudan University,Shanghai 200040,China;Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China)

机构地区：[1]复旦大学附属华山医院,上海200040 [2]上海交通大学医学院附属精神卫生中心,上海200032

出　　处：《四川精神卫生》2020年第4期349-353,共5页Sichuan Mental Health

基　　金：国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项(项目名称:抗精神病药物个体化优选治疗方案的研究,项目编号:2016YFC1306900);上海市重性精神病重点实验室开放课题项目(项目名称:电休克治疗对抑郁症海马磁共振波谱及认知功能影响的相关研究,项目编号:13dz2260500);上海市级医院新兴前沿技术联合攻关项目(项目名称:MECT疗效及认知障碍的临床研究及规范化干预技术推广研究,项目编号:SHDC12012109)。

摘　　要：目的对传染性非典型肺炎(SARS)期间医务人员感染者的抑郁情绪发生率及其危险因素进行系统评价。方法检索PubMed、Embase、Web of Science、Cochrane Library、中国知网、万方数据库、中文科技期刊数据库、中国生物医学文献数据库,纳入报道了感染SARS的医务人员抑郁情绪发生率及其危险因素的文献。应用加强观察性流行病学研究报告规范(STROBE)声明为参照标准评价文献质量,采用MedCalc 18.6进行Meta分析。结果共10项研究纳入系统评价,其中5项研究报道了医务人员感染者抑郁情绪的发生率,为10.53%~43.12%,随机效应Meta分析结果显示,总样本量为989例,感染SARS的医务人员抑郁情绪发生率为22.76%(95%CI:13.63%~33.43%)。抑郁的危险因素为年纪轻、工作暴露、隔离等。结论感染SARS的医务人员抑郁情绪发生率较高。Objective To systematically evaluate the prevalence rate of depression and its risk factors among medical staff infected with severe acute respiratory syndrome(SARS).Methods Randomized controlled clinical trials(RCTs)published on PubMed,Embase,Web of Science,Cochrane Library,CNKI,Wanfang,VIP database and China Biology Medicine disc were retrieved,and literatures which reported the incidence of depression and its risk factors among medical staff infected with SARS were included.The quality of selected literature was evaluated using Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)statement.Meta-analysis was completed by Med Calc 18.6.Results A total of 10 studies were included in the systematic review,among which 5 studies reported the incidence of depression among infected medical staff(10.53%~43.12%).Random-effects Meta-analysis showed that the total sample size was 989 cases,and the incidence of depression among medical staff infected with SARS was 22.76%(95%CI:13.63%~33.43%).Risk factors for depression of infected medical stuff included young age,work exposure and isolation.Conclusion Medical staff infected with SARS suffer a high risk of depression.

关 键 词：SARS 冠状病毒 抑郁 发生率 Meta分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]