NLR、LMR对晚期非小细胞肺癌患者预后的预测价值  

Prognostic value and correlation analysis of NLR and LMR in patients with advanced non-small cell lung cancer

作　　者：吴越菲[1] 江伟[1] 齐志峰[1] 徐礼鹏 Wu Yuefei;Jiang Wei;Qi Zhifeng;Xu Lipeng(Department of Interventional,Second People′s Hospital of Wuhu,Wuhu 241000,China)

机构地区：[1]安徽省芜湖市第二人民医院介入科,241000

出　　处：《中国医师杂志》2020年第8期1216-1219,共4页Journal of Chinese Physician

摘　　要：目的探讨晚期非小细胞肺癌(NSCLC)患者外周血中中性粒细胞/淋巴细胞比值(NLR)、淋巴细胞/单核细胞比值(LMR)与患者预后的关系。方法选取2014年3月至2016年10月本院收治的经病理学检查证实的ⅢB期以及其以上分期的NSCLC患者96例作为研究对象,根据24个月的随访结果将患者分为生存组30例、死亡组66例,对比两组实施化疗前的NLR、LMR值;通过绘制受试者工作曲线(ROC)分析NLR、LMR预测患者预后的临界值;并分析不同NLR、LMR水平的NSCLC患者临床病理学特征差异;采用Cox比例风险回归模型分析NLR、LMR对患者预后的影响。结果生存组的NLR值低于死亡组(P<0.05),生存组和死亡组的LMR值比较差异无统计学意义(P>0.05)。绘制ROC曲线,NLR值预测患者预后的AUC值为0.785、对应的临界值为3.19;LMR预测患者预后的AUC值为0.536,对应的临界值为3.66。不同NLR值的NSCLC患者(NLR≥3.19组与NLR<3.19组)其TNM分期及分化程度差异有统计学意义(P<0.05),而年龄、性别、吸烟、病理学类型、病灶部位的差异无统计学意义(P>0.05)。不同LMR值的NSCLC患者(LMR≥3.66组与LMR<3.66组)其TNM分期、分化程度、年龄、性别、吸烟、病理学类型、病灶部位的差异无统计学意义(P>0.05)。TNM分期增加、分化程度增加、NLR升高是晚期NSCLC患者不良预后的独立危险因素(P<0.05)。结论晚期NSCLC患者外周血中NLR值升高会增加患者不良预后的风险。Objective To investigate the relationship between neutrophil/lymphocyte ratio(NLR),lymphocyte/monocyte(LMR)ratio and prognosis in patients with advanced non-small cell lung cancer(NSCLC).Methods Total 96 NSCLC patients with stageⅢB and above confirmed by pathological examination in our hospital from March 2014 to 2016 were selected as the research objects.According to the 24-month follow-up results,the patients were divided into survival group(30 cases)and death group(66 cases).The NLR and LMR values of the two groups before chemotherapy were compared.The critical value of NLR and LMR in predicting the prognosis of patients was analyzed by drawing receiver operating curve(ROC);The clinicopathological characteristics of NSCLC patients with different levels of NLR and LMR were analyzed,and Cox proportional hazard regression model was used to analyze the effect of NLR and LMR on the prognosis of patients.Results The NLR value of survival group was lower than that of death group(P<0.05),and there was no significant difference between survival group and death group in LMR value(P>0.05).The area under curve(AUC)value of NLR was 0.785,and the corresponding critical value was 3.19;the AUC value of LMR was 0.536,and the corresponding critical value was 3.66.There were significant difference in tumor node metastasis(TNM)stage and differentiation between NSCLC patients with different NLR values(NLR≥3.19 group and NLR<3.19 group)(P<0.05),but there were no significant differences in age,gender,smoking,pathological type and lesion location(P>0.05).There was no significant difference in TNM stage,differentiation degree,age,gender,smoking,pathological type and lesion location in NSCLC patients with different LMR values(LMR≥3.66 group and LMR<3.66 group)(P>0.05).The increase of TNM stage,differentiation degree and NRL were independent risk factors of poor prognosis in patients with advanced NSCLC(P<0.05).Conclusions Increased NLR values in peripheral blood of patients with advanced NSCLC may increase the risk of poor progno

关 键 词：癌 非小细胞肺 中性粒细胞/淋巴细胞比值 淋巴细胞/单核细胞比值 预后 

分 类 号：R734.2[医药卫生—肿瘤]