浅表宫颈阴道肌纤维母细胞瘤3例并文献复习  

Superficial Cervical Vaginal Myofibroblastoma in 3 Cases and Literature Review

作　　者：杨超 杨育妮 谢娱新 王靖莹 陈晓旭 姜婷 路英丽[1] YANG Chao;YANG Yu-ni;XIE Yu-xin;WANG Jing-ying;CHEN Xiao-xu;JIANG Ting;LU Ying-li(The Second Hospital of Jilin University,Changchun 130022,China)

机构地区：[1]吉林大学第二医院,长春130022

出　　处：《国际妇产科学杂志》2020年第4期474-477,共4页Journal of International Obstetrics and Gynecology

摘　　要：浅表宫颈肌纤维母细胞瘤是一种罕见的、新近公认的良性肿瘤。现对吉林大学第二医院妇产科收治的3例浅表宫颈阴道肌纤维母细胞瘤患者的临床资料进行回顾性分析。3例患者中,2例发生于绝经后,临床均表现为阴道肿物。大体上,肿物呈类圆形,边界清晰,肿物大小约为3.0~4.0 cm。镜下见肿物由均一的梭形和星状细胞组成,周边区肿瘤细胞成分相对稀疏,中心区肿瘤细胞相对密集。免疫组织化学(免疫组化)染色示:波形蛋白(Vimentin)(+)、结蛋白(Desmin)(+)、CD34(-)、雌激素受体(ER)(+)、孕激素受体(PR)(+)、平滑肌肌动蛋白(SMA)(-)、S-100(-)。通过对此类病例的阐述,提示浅表宫颈阴道肌纤维母细胞瘤主要影响外阴、阴道及宫颈区域,易与纤维上皮性息肉、孤立性纤维性肿瘤、血管肌纤维母细胞瘤等混淆,明确诊断需结合病理学形态、免疫组化及临床资料。Superficial cervical vaginal myofibroblastoma is a rare and newly recognized benign tumor.The clinical data of 3 patients with superficial cervical vaginal myofibroblastoma treated in the Department of Obstetrics and Gynecology of the Second Hospital of Jilin University were reviewed retrospectively.Of the 3 patients,2 were postmenopausal and clinically manifested as a vaginal mass.In general,the mass was round,with clear boundaries,and the size of the mass was about 3.0-4.0 cm.Under the microscope,the tumor was composed of uniform spindle and stellate cells.The tumor cells in the peripheral area were relatively sparse and the tumor cells in the central area were relatively dense.Immunohistochemical staining showed:Vimentin(+),Desmin(+),CD34(-),ER(+),PR(+),SMA(-),S-100(-).Through the elaboration of such cases,it is suggested that superficial cervical vaginal myofibroblastoma mainly affects the vulva,vagina and cervical area,and is easily confused with fibrous epithelial polyps,solitary fibrous tumors,and vascular myofibroblastoma.The definite diagnosis needs to be combined with pathological morphology,immunohistochemistry and clinical data.

关 键 词：浅表宫颈阴道肌纤维母细胞瘤 诊断 诊断 鉴别 病理学 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]