恩替卡韦联合前列地尔治疗乙肝肝硬化合并肝源性糖尿病临床效果分析  

Clinical effect of entecavir combined with alprostadil in the treatment of hepatitis B cirrhosis complicated with hepatogenous diabetes

作　　者：宋香妮 曹娟 SONG Xiangni;CAO Juan(Department of Gastroenterology,Tongchuan People’s Hospital,Shaanxi Province,Tongchuan 727000)

机构地区：[1]陕西省铜川市人民医院消化内科,铜川727000

出　　处：《陕西医学杂志》2020年第9期1145-1148,共4页Shaanxi Medical Journal

摘　　要：目的:探讨恩替卡韦联合前列地尔治疗乙肝肝硬化合并肝源性糖尿病的临床效果。方法:选取75例乙肝肝硬化合并肝源性糖尿病患者,分为对照组(37例)和观察组(38例)。对照组在内科常规治疗的基础上给予恩替卡韦,观察组在对照组的基础上给予前列地尔,治疗12周。观察两组患者治疗前后的肝功能、肝纤维化及血糖水平等指标的变化。结果:两组谷丙转氨酶(GPT)、谷草转氨酶(GOT)均低于治疗前水平,白蛋白(ALB)均高于治疗前水平;Ⅲ型前胶原(PCⅢ)、透明质酸(HA)、层粘连蛋白(LN)水平均低于治疗前;空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)水平均低于治疗前。同时,观察组上述指标水平均低于对照组,除FPG水平无统计学差异外,其他指标均有统计学差异(均P<0.05)。结论:恩替卡韦联合前列地尔治疗乙肝肝硬化合并肝源性糖尿病临床效果较好,可明显改善患者肝功能、肝纤维化及糖代谢。Objective:To investigate the clinical effect of entecavir combined with alprostadil in the treatment of hepatitis B cirrhosis with hepatogenous diabetes.Methods:75 cases of hepatitis B cirrhosis patients complicated with hepatogenous diabetes were divided into control group(37 cases)and observation group(38 cases).The control group was given entecavir on the basis of conventional medical treatment,and the observation group was given alprostadil on the basis of the control group for 12 weeks.The changes of liver function index,liver fibrosis index and blood glucose level before and after treatment were observed.Results:The levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were lower than the pre-treatment levels,and albumin(ALB)was higher than the pre-treatment level.The levels of typeⅢprocollagen(PCⅢ),hyaluronic acid(HA),laminin(LN)were lower than those before treatment.The levels of fasting blood glucose(FPG),2-hour postprandial glucose(2hPG)and glycosylated hemoglobin A1c(HbA1c)were lower than those before treatment.At the same time,the levels of the above mentioned indicators in the observation group were lower than those in the control group,with statistical difference(all P<0.05)except FDP.Conclusion:Entecavir combined with alprostadil has a good clinical effect in the treatment of hepatitis B cirrhosis complicated with hepatogenous diabetes,which can significantly improve liver function,liver fibrosis and glucose metabolism.

关 键 词：乙肝肝硬化 肝源性糖尿病 恩替卡韦 肝硬化 乙肝 预后 

分 类 号：R575.2[医药卫生—消化系统]