Pestaloamides A and B,two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp.HS30  

作　　者：Xiao-Zheng Su Yi-Ying Zhu Jian-Wei Tang Kun Hu Xiao-Nian Li Han-Dong Sun Yan Li Pema-Tenzin Puno 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Yunnan Key Laboratory of Natural Medicinal Chemistry,Kunming 650201,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China Chemistry》2020年第9期1208-1213,共6页中国科学（化学英文版）

基　　金：the Second Tibetan Plateau Scientific Expedition and Research(STEP)Program(2019QZKK0502);the National Natural Science Foundation of China(81874298);the CAS“Light of West China”Program(Pema-Tenzin Puno);the Yunnan Science Fund for Distinguished Young Scholars(2019FJ002)。

摘　　要：Pestaloamides A and B(1 and 2),two novel alkaloids featuring an unprecedented spiro[imidazothiazoledione-alkylidenecyclopentenone]scaffold,were obtained from the cultures of an endophytic fungus Pestalotiopsis sp.HS30 which inhabited the stems of Isodon xerophilus.Their planar structures and absolute configurations were fully determined by extensive spectroscopic analysis and X-ray crystallography.In addition,both compounds 1 and 2 showed the latent tumor immunotherapy activity through markedly promoting the cell surface engagement of NKG2 D ligands involving MICA/B and ULBP1 in HCT116 cells.

关 键 词：ALKALOIDS endophytic fungus structure elucidation tumor immunotherapy 

分 类 号：O629.3[理学—有机化学] O641.6[理学—化学]