Activatable nanoscale metal-organic framework for ratiometric photoacoustic imaging of hydrogen sulfide and orthotopic colorectal cancer in vivo  

作　　者：Wenmin Zhang Jun Wang Lichao Su Hui Chen Lan Zhang Lisen Lin Xiaoyuan Chen Jibin Song Huanghao Yang 

机构地区：[1]College of Chemical Engineering,Fuzhou University,Fuzhou 350116,China [2]Key Laboratory for Analytical Science of Food Safety and Biology,Ministry of Education,College of Chemistry,Fuzhou University,Fuzhou 350116,China [3]Laboratory of Molecular Imaging and Nanomedicine,National Institute of Biomedical Imaging and Bioengineering,National Institutes of Health,Bethesda,MD 20892,USA

出　　处：《Science China Chemistry》2020年第9期1315-1322,共8页中国科学（化学英文版）

基　　金：the National Nature Sciences Foundation of China(21635002;21874024);the joint research projects of Health and Education Commission of Fujian Province(2019-WJ-20);the Intramural Research Program,National Institute of Biomedical Imaging and Bioengineering;National Institutes of Health。

摘　　要：Nanoscale metal-organic frameworks(nano MOFs)have emerged as a promising biomedical nanoplatform because of their unique properties.However,the exploration of nano MOFs in photoacoustic(PA)imaging is still limited.Here,a novel hydrogen sulfide(H2 S)-activated nano copper-based MOF(Cu-MOF)was developed as a near-infrared(NIR)ratiometric PA probe for in vivo monitoring of endogenous H2 S level and orthotopic colorectal cancer imaging via in situ reaction of nano Cu-MOFs with endogenous H2 S that is closely associated with tumor growth and proliferation in colon cancer.The synthesized nano Cu-MOFs displayed excellent PA responsiveness towards tumor H2 S level with high selectivity and rapid kinetics.The result suggests the developed probe may provide a unique opportunity to investigate the malignant behaviors of H2 S-associated events in vivo.

关 键 词：PA imaging MOFs ratiometric probe H2S orthotopic colorectal cancer 

分 类 号：R735.34[医药卫生—肿瘤] O641.4[医药卫生—临床医学]