Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance  

作　　者：Lili Niu Yanchen Guo Zhengrong Lin Zhe Shi Tianyuan Bian Lin Qi Long Meng Anthony AGrace Hairong Zheng Ti-Fei Yuan 

机构地区：[1]Paul C.Lauterbur Research Center for Biomedical Imaging,Institute of Biomedical and Health Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [2]Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China [3]Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province,Hunan University of Chinese Medicine,Changsha 410208,China [4]College of Medicine and Biological Information Engineering,Northeastern University,Shenyang 110016,China [5]Departments of Neuroscience,Psychiatry and Psychology,University of Pittsburgh,Pittsburgh,PA 15260,USA [6]Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China

出　　处：《Science China(Life Sciences)》2020年第9期1328-1336,共9页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(81527901,81822017,11534013,11774371,31771215);Youth Innovation Promotion Association CAS(2018393);sponsored by the Science and Technology Commission of Shanghai Municipality(18QA1403700,18JC1420304,18140901700);Shanghai Clinical Research Center for Mental Health(19MC1911100)。

摘　　要：Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens(NAc) in freely moving mice. Our results show that an acute ultrasound stimulation on the NAc, rather than the visual cortex or auditory cortex, led to a pronounced avoidance behavior, while repeated NAc ultrasound stimulation resulted in an obvious conditioned place aversion with changes in synaptic protein(Glu A1/2 subunit) expression. Notably, NAc ultrasound stimulation suppressed the morphine-induced conditioned place preference. The results provide evidence that NAc ultrasound stimulation can be applied as a potential noninvasive therapeutic option in treating psychiatric disorders.

关 键 词：ULTRASOUND nucleus accumbens ADDICTION synaptic plasticity brain stimulation 

分 类 号：R749.05[医药卫生—神经病学与精神病学]