普拉洛芬与盐酸氮卓斯汀联合治疗小儿变态反应性结膜炎效果观察  

Effect of praprofen and azelastine hydrochloride on the treatment of allergic conjunctivitis in children

作　　者：刘金鸣 罗建波 LIU Jinming;LUO Jianbo(Department of Ophthalmology,Wuhua Mingxin Hospital,Meizhou 514400,China)

机构地区：[1]梅州市五华明鑫医院眼科,广东梅州514400

出　　处：《包头医学院学报》2020年第5期19-21,共3页Journal of Baotou Medical College

摘　　要：目的:探讨普拉洛芬联合盐酸氮卓斯汀治疗小儿变态反应性结膜炎效果。方法:选取2018年1月至2020年4月收治的90例(180眼)变态反应性结膜炎患儿,随机分为观察组和对照组,观察组给予普拉洛芬与盐酸氮卓斯汀联合治疗,对照组给予普拉洛芬治疗,比较两组临床疗效、治疗前后临床症状评分、泪膜稳定性、泪液中炎性因子水平。结果:观察组临床疗效总有效率为95.56%,高于对照组的82.22%(P<0.05);治疗前两组临床症状评分差异无统计学意义(P>0.05),治疗后两组眼痒、流泪、异物感、畏光症状评分均下降,且观察组眼痒、流泪、异物感、畏光症状评分低于对照组(P<0.05);治疗前两组泪膜破裂时间(BUT)、角膜荧光素染色试验(FL)指标差异无统计学意义(P>0.05),治疗后两组BUT均上升,FL均下降,且观察组BUT高于对照组、FL低于对照组(均为P<0.05);治疗前两组泪液中炎性因子水平差异无统计学意义(P>0.05),治疗后两组泪液中组胺(HA)、嗜酸粒细胞阳离子蛋白(ECP)、免疫球蛋白E(IgE)水平均下降,且观察组泪液中HA、ECP、LgE均低于对照组(均为P<0.05);观察组不良反应发生率为8.89%,低于对照组的28.88%(P<0.05)。结论:普拉洛芬与盐酸氮卓斯汀联合治疗小儿变态反应性结膜炎可提高临床疗效,改善临床症状,降低炎症反应,促进泪膜功能的恢复,值得推广应用。Objective:To explore and analyze the effect of praprofen and azelastine hydrochloride on the treatment of allergic conjunctivitis in children.Methods:90 cases(180 eyes)of children with allergic conjunctivitis admitted from January 2018 to April 2020 were selected and randomly divided into observation group and control group.The observation group was given pranoprofen combined with azelastine hydrochloride,and the control group was given praprofen.The clinical efficacy,clinical symptom scores before and after treatment,the stability of tear film and the levels of inflammatory factors in tears were compared between the two groups.Results:The total effective rate of clinical efficacy in the observation group was 95.56%,which was significantly higher than that in the control group(82.22%)(P<0.05).There was no significant difference of clinical symptom scores before treatment(P>0.05).After treatment,the scores of itching,tearing,foreign body sensation,and photophobia symptoms in both groups were significantly decreased,and the observation group had more significant drop in itching,tearing,foreign body sensation,and photophobia symptoms(P<0.05).There was no significant difference between BUT and PL indexes of the two groups before treatment(P>0.05).After treatment,BUT indexes of the two groups increased significantly,the FL indexes decreased significantly,and the changes in the observation group were more significant(P<0.05).There was no significant difference in the levels of inflammatory factors in tears before treatment(P>0.05).After treatment,the levels of HA,ECP and LgE decreased significantly,and the levels in the observation group decreased more significantly than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 8.89%,which was significantly lower than that of the control group(28.88%)(P<0.05).Conclusion:The combined treatment of praprofen and azelastine hydrochloride in children with allergic conjunctivitis can significantly improve the clinical efficacy,improve

关 键 词：普拉洛芬 盐酸氮卓斯汀 变态反应性结膜炎 儿童 

分 类 号：R777.31[医药卫生—眼科]