表阿霉素-明胶海绵微粒(EPI-GSP)栓塞治疗大肝癌的近期疗效  

Short-term Efficacy of Epirubicin-gelatin Sponge Particles(EPI-GSP)Embolization in the Treatment of Large Hepatocellular Carcinoma

作　　者：谢兴武 熊妍希 唐先志 敖锋 陈光斌 XIE Xing-wu;XIONG Yan-xi;TANG Xian-zhi;AO Feng;CHEN Guangbin(Department of Radiology,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China;Institution of Radiological Imaging,Renmin Hospital,Hubei University of Medicine,Shiyan,Hubei 442000,China)

机构地区：[1]十堰市人民医院·湖北医药学院附属人民医院放射影像中心,湖北十堰442000 [2]十堰市人民医院·湖北医药学院附属人民医院放射影像研究所,湖北十堰442000

出　　处：《湖北医药学院学报》2020年第4期371-374,385,共5页Journal of Hubei University of Medicine

基　　金：十堰市科技局引导性科研项目(19Y02)。

摘　　要：目的:探究表阿霉素-明胶海绵微粒(Epirubici-Gelatin sponge particulate,EPI-GSP)栓塞治疗大肝癌的近期疗效。方法:收集我院2017年12月至2018年12月确诊大肝癌的52例患者,均行TACE治疗,其中观察组27例患者采用表阿霉素-明胶海绵微粒(EPI-GSP)混悬液进行栓塞,对照组25例患者采用表阿霉素及空白明胶海绵微粒序贯栓塞,对比两组患者术后不良反应及术后6个月肿瘤反应情况。结果:两组患者在随访过程中均未出现严重的不良反应,不良反应发生率差异无统计学意义(P>0.05);观察组的肿瘤部分缓解(PR)率及总缓解率(ORR)高于对照组,差异有统计学意义(P<0.05)。结论:表阿霉素-明胶海绵微粒(EPI-GSP)混悬液栓塞治疗大肝癌较序贯栓塞具有更好的近期疗效,具有一定的药物缓释作用,可供临床采用。Objective To explore the short-term efficacy of epirubicin-gelatin sponge particles(EPI-GSP) embolization in the treatment of large hepatocellular carcinoma. Methods 52 patients diagnosed with large liver cancer in our hospital from December 2017 to December 2018 were collected and treated with TACE. 27 patients in the observation group were embolized with epirubicin gelatin sponge particles(EPI-GSP) suspension, and 25 patients in the control group were treated with sequential embolization with epirubicin and blank gelatin sponge particles. The adverse reactions after the operation and the tumor reactions at 6 months after the operation were compared between the two groups. Results There were no serious side effects in the two groups during the follow-up, and there was no statistical difference in the incidence of side effects(P>0.05). The partial remission(PR) rate and total remission rate(ORR) of the observation group were higher than those of the control group, and the difference was statistically significant(P<0.05). Conclusion Epirubicin gelatin sponge particles(EPI-GSP) suspension has better short-term efficacy than sequential embolization, and has a certain drug slow-release effect, which can be used in clinical practice.

关 键 词：明胶海绵微粒 阿霉素 大肝癌 肝动脉化疗栓塞 

分 类 号：R735.7[医药卫生—肿瘤]