有机锌试剂的制备及其在酰基化合物合成中的应用  

Preparation of Organozinc Reagent and Its Application in the Synthesis of Acyl Compounds

作　　者：李明[1] 李学强[1,3] 魏梦雪[1,2] LI Ming;LI Xue-qiang;WEI Meng-xue(National Demonstration Center for Experimental Chemistry Education College of Chemistry and Chemical Engineering,Ningxia University,Yinchuan 750021,China;State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering,Ningxia University,Yinchuan 750021,China;Ningxia Engineering Research Center for Natural Medicine,Ningxia University,Yinchuan 750021,China)

机构地区：[1]宁夏大学化学化工学院化学国家级实验教学示范中心,宁夏银川750021 [2]宁夏大学省部共建煤炭高效利用与绿色化工国家重点实验室,宁夏银川750021 [3]宁夏大学宁夏天然药物工程技术研究中心,宁夏银川750021

出　　处：《合成化学》2020年第7期608-613,共6页Chinese Journal of Synthetic Chemistry

基　　金：宁夏高等教育教学改革项目(nxbjg-21);宁夏大学创新创业教育教学改革项目(CXJG2019002);宁夏自然科学基金项目(2019AAC03018);第三批宁夏青年科技人才托举工程项目(TJGC2018100);宁夏回族自治区国内一流学科建设项目(NXYLXK2017A04)。

摘　　要：采用“一锅煮”法,经无机酸活化的锌粉与卤代烃反应制备有机锌化合物,并直接与酰基化试剂(酰卤或酸酐)反应合成了酰基类化合物(a^g)。所有化合物的结构由1 H NMR,13 C NMR,IR和HR-MS(ESI)确证。The zinc powder was activated by an inorganic acid and then reacted with a halogenated hydrocarbon to prepare an organozinc compound,which was then reacted with an acylating reagent(acid halide or anhydride)in a one-pot method to obtain acyl compounds(a^g).The structures of the acyl compounds were confirmed by 1 H NMR,13 C NMR,IR,and HR-MS(ESI)

关 键 词：锌粉 一锅煮 有机锌试剂 酰基化合物 合成 卤代烃 

分 类 号：O621.25[理学—有机化学] O626[理学—化学]