胃癌组织中AEG-1、HER2的表达及临床意义  

The expression of AEG-1、HER2 in gastric carcinoma and its clinical significance

作　　者：黄勇[1] 王静[1] 鲍广建[1] 伦增军[1] 褚朋[1] 支良[1] Huang Yong;Wang Jing;Bao Guangjian;Lun Zengjun;Chu Peng;Zhi Liang(Department of General Surgery,Zaozhuang Municipal Hospital,Zaozhuang 277100,China)

机构地区：[1]枣庄市立医院普通外科,山东枣庄277100

出　　处：《中华普外科手术学杂志（电子版）》2020年第5期487-490,共4页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：山东省医药卫生科技发展计划(2018WS013)。

摘　　要：目的探讨胃癌组织中AEG-1、HER-2的表达及与胃癌临床病理特征的相关性。方法收集2013年1月至2018年1月96例胃癌患者组织切片,采用免疫组织化学法检测AEG-1、HER-2表达情况。在以上胃癌患者中随机选取20例,取距肿瘤5 cm以上的癌旁胃组织作为对照组。使用SPSS16.0统计软件进行分析,依据不同分析目的分别采用χ2检验、线性趋势检验、Spearman等级相关分析及Kaplan-Meier生存分析,P<0.05为差异有统计学意义。结果胃癌组织中AEG-1阳性表达率(76.0%)明显高于癌旁胃组织(0%),其阳性表达率与分化程度、TNM分期、淋巴结转移有关(P<0.05)。胃癌组织中HER2阳性表达率(41.7%)明显高于癌旁胃组织(0%),其阳性表达率与分化程度、浸润深度、TNM分期、淋巴结转移有关(P<0.05)。胃癌组织中AEG-1、HER2阳性表达呈正相关(r=0.276,P=0.007)。Kaplan-Meier生存分析提示胃癌中AEG-1及HER2双阴性表达患者的预后(平均生存期:31.1个月)优于AEG-1及HER2双阳性表达患者(平均生存期:48.3个月)。结论胃癌组织中可能存在AEG-1、HER2信号通路。检测胃癌组织中AEG-1、HER2的表达,有利于判断胃癌的发生、发展、浸润、转移及预后。Objective To investigate the expression of AEG-1、HER2 in gastric cancer tissue and its relationship with clinical-pathological features.Methods The expression of AEG-1、HER2 in 96 cases of patients with gastric cancer from January 2013 to January 2018 were detected by immunohistochemical method.The paracancerous tissues were selected randomly from 20 cases as the control group.We observed the association of AEG-1、HER2 in gastric carcinoma and its relationship with clinical pathological features Statistical procedures were done using SPSS version 16.0.Comparison between qualitative data was performed using Chi-square test,Linear trend test,Spearman correlation analysis or Kaplan-Meier survival curves according to different analytical purposes respectively.P<0.05 was considered as statistically significant.Results The positive expression of AEG-1 in gastric cancer(76.0%)was significantly higher than that in adjacent normal gastric tissue(0%).The positive expression of AEG-1 in gastric cancer was closely correlated with differentiation degree、clinical TNM stages and lymph node metastasis(P<0.05).The positive expression of HER2 in gastric cancer(41.7%)was significantly higher than that in adjacent normal gastric tissue(0%).The positive expression of HER2 in gastric cancer was closely correlated with differentiation degree、invasion depth、clinical TNM stages and lymph node metastasis(P<0.05).Spearman correlation analysis showed that there was a line relationship between AEG-1 and HER2 in gastric cancer(r=0.276,P=0.007).Kaplan-Meier survival curves showed the survival time of patients with the dual-negative expression of AEG-1 and HER2(Mean survival time:48.3 months)had significantly longer than that with the dual-positive expression of AEG-1 and HER2(Mean survival time:31.1 months)(P<0.05).Conclusion There may be AEG-1、HER2 signaling pathway in gastric carcinoma.Detecting the expression of AEG-1、HER2 in gastric cancer tissues could judge the occurrence、development、invasion and metastasis of gastric c

关 键 词：胃肿瘤 基因 ERBB-2 AEG-1 病理学特征 

分 类 号：R735.2[医药卫生—肿瘤]