铝碳酸镁联合雷尼替丁治疗胃食管反流病患者的效果观察  

Observation on Effect of Hydrotalcite Combined with Ranitidine in the Treatment of Patients with Gastroesophageal Reflux Disease

作　　者：刘芳 LIU Fang(The People's Hospital of Shangcai County,Zhumadian 463800,China)

机构地区：[1]河南省上蔡县人民医院,河南驻马店463800

出　　处：《临床医学工程》2020年第9期1187-1188,共2页Clinical Medicine & Engineering

摘　　要：目的观察铝碳酸镁联合雷尼替丁治疗胃食管反流病患者的临床效果。方法选择2018年1月至2019年3月我院收治的102例胃食管反流病患者,随机分为两组各51例。对照组采用雷尼替丁联合阿莫西林治疗,观察组采用铝碳酸镁联合雷尼替丁治疗,比较两组的临床疗效、症状积分、食管pH值及不良反应情况。结果观察组治疗总有效率为92.16%,明显高于对照组的76.47%(P<0.05)。治疗前,两组的症状积分及食管pH值总时间占比比较无统计学差异(P>0.05);治疗后,两组的症状积分、第一通道pH<4总时间占比、第二通道pH<4总时间占比均低于治疗前,且观察组的症状积分、第一通道pH<4总时间占比、第二通道pH<4总时间占比低于对照组(P<0.05);两组的不良反应发生率比较无统计学差异(P>0.05)。结论铝碳酸镁联合雷尼替丁治疗胃食管反流病效果显著,可有效改善患者相关临床症状,控制食管pH值,且安全性较高,值得临床推广应用。Objective To observe the clinical effect of hydrotalcite combined with ranitidine in the treatment of patients with gastroesophageal reflux disease.Methods 102 patients with gastroesophageal reflux disease admitted to our hospital from January 2018 to March 2019 were selected and randomly divided into two groups,with 51 cases in each group.The control group was treated with ranitidine combined with amoxicillin,and the observation group was treated with hydrotalcite combined with ranitidine.The clinical efficacy,symptom score,esophageal p H value and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.16%,significantly higher than 76.47%in the control group(P<0.05).Before treatment,no statistical difference was found in the symptom score and total esophageal pH time ratio between the two groups(P>0.05).After treatment,the symptom scores,the first channel pH<4 total time ratio and the second channel pH<4 total time ratio of the two groups were lower than those before treatment,and the symptom score,the first channel pH<4 total time ratio and the second channel pH<4 total time ratio of the observation group were lower than those of the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Hydrotalcite combined with ranitidine has significant effect in the treatment of gastroesophageal reflux disease,can effectively improve the clinical symptoms of patients,control the esophageal pH,with higher safety,which is worthy of clinical promotion and application.

关 键 词：胃食管反流病 铝碳酸镁 雷尼替丁 症状积分 食管PH值 

分 类 号：R571[医药卫生—消化系统]