翼状胬肉切除联合带蒂结膜瓣移植术新技术应用效果及安全性分析  

Effect and safety analysis of a new technique of pterygium excision combined with pedicled conjunctival flap transplantation

作　　者：陈启超 李宁[2] 殷义平[1] 姚有根 CHEN Qi-chao;LI Ning;YIN Yi-ping;YAO You-gen(Department of Ophthalmology,Chizhou People′s Hospital,Chizhou Anhui 247000;Department of Ophthalmology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]安徽省池州市人民医院眼科,247000 [2]蚌埠医学院第一附属医院眼科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2020年第8期1033-1036,共4页Journal of Bengbu Medical College

基　　金：蚌埠医学院转化医学重点项目(BYTM2019025);安徽省高校自然科学研究项目(KJ2019A1282)。

摘　　要：目的:探讨翼状胬肉切除联合带蒂结膜瓣移植术新技术应用效果及安全性分析。方法:选取翼状胬肉手术病人100例(103眼),使用随机数字表法分为观察组和对照组。其中,观察组50例(53眼),采用改良后的翼状胬肉切除联合带蒂结膜瓣移植术(带蒂结膜瓣的形状制成梯形,符合手术缺损区形态,减少结膜剪除量,缝线少);对照组50例(50眼),采取翼状胬肉切除联合自体角膜缘干细胞移植术;均随访6个月,比较2组病人手术时间、结膜瓣愈合时间、复发率、术后4周最佳矫正视力以及术后并发症情况。结果:观察组与对照组相比,手术时间、结膜瓣愈合时间更短、术后刺激症状轻(P<0.05~P<0.01),术后随访6月内复发率差异无统计学意义(P>0.05),2组病人术后4周最佳矫正视力以及术后睑球粘连并发症比较差异均无统计学意义(P>0.05)。结论:翼状胬肉切除联合带蒂结膜瓣移植术新技术临床疗效理想,安全性较高,具有一定的临床推广价值。Objective:To explore the effects and safety of the new technique of pterygium excision combined with pedicled conjunctival flap transplantation.Methods:One hundred patients(103 eyes)with pterygium surgery were divided into the observation group and control group according to the random number table(50 cases in each group).The observation group(53 eyes)was treated with the modified pterygium excision combined with pedicled conjunctival flap transplantation(the shape of pedicled conjunctival flap was made into trapezoid,which was consistent with the shape of surgical defect area,the amount of conjunctival cutting reduced,the suture was less.The control group(50 eyes)was treated with simple resection combined with stem cell transplantation.Two groups were followed up for 6 months,and the operation time,conjunctival flap healing time,recurrence rate,best corrected visual acuity after 4 weeks of operation and postoperative complications were compared between two groups.Results:Compared with the control group,the operation time and conjunctival flap healing time were shorter,and the postoperative irritation symptoms was lighter in the observation group(P<0.05 to P<0.01),the difference of the recurrence rate between two groups was not statistically significant within 6 months of following-up(P>0.05),and there was no statistical significance in the best corrected visual acuity and symblepharon complications after 4 weeks of operation between two groups(P>0.05).Conclusions:The new technique of pterygium excision combined with pedicled conjunctival flap transplantation has ideal clinical effects,high safety and certain clinical promotion value.

关 键 词：翼状胬肉切除术 结膜瓣 安全性 干细胞移植 

分 类 号：R777.33[医药卫生—眼科]