缺血性脑卒中患者血清促红细胞生成素与血液流变学的关系分析  

Analysis of relationship between blood EPO and hemorheology in patients with ischemic stroke

作　　者：王鑫 薛莉 李转会 崔长富 燕飞 张妮 WANG Xin;XUE Li;LI Zhuanhui;CUI Changfu;YAN Fei;ZHANG Ni(Department of Neurology,521 Hospital of Norinco Group,Xi′an,Shaanxi 710065,China)

机构地区：[1]兵器工业五二一医院神经内科,陕西西安710065

出　　处：《检验医学与临床》2020年第17期2436-2438,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨缺血性脑卒中患者血清促红细胞生成素(EPO)与血液流变学的关系。方法选取2018年4月至2019年4月于该院接受治疗的118例缺血性脑卒中患者作为观察组,另外选取同期106例无脑血管疾病患者作为对照组。检测两组患者血清EPO、血常规及血液流变学指标水平,采用Spearman相关分析不同指标与两组患者血清EPO的相关性。结果观察组血清EPO、血浆黏度、红细胞沉降率、全血高切黏度、全血低切黏度水平明显高于对照组,差异有统计学意义(P<0.05)。观察组红细胞计数、血细胞比容、血红蛋白水平明显低于对照组,差异有统计学意义(P<0.05)。相关性分析结果显示,对照组血浆黏度、红细胞沉降率、全血高切黏度、全血低切黏度、红细胞计数、血细胞比容、血红蛋白与血清EPO无相关性(P>0.05);观察组血浆黏度、红细胞沉降率与血清EPO呈正相关(r=0.347、0.431,P<0.05),观察组红细胞计数、血细胞比容、血红蛋白与血清EPO呈负相关(r=-0.218、-0.543、-0.546,P<0.05)。结论缺血性脑卒中患者血清EPO、血常规、血液流变学指标与未发生缺血性脑卒中患者比较存在一定差异,多个血常规及血液流变学指标与缺血性脑卒中患者血清EPO水平存在相关性,临床医生可以根据血清EPO与血液流变学指标相关性对患者临床特点做进一步分析。Objective To explore the relationship between blood erythropoietin(EPO)and hemorheology in patients with ischemic stroke.Methods A total of 118 patients with ischemic stroke who were treated in 521 Hospital of Norinco Group from April 2018 to April 2019 were enrolled as the observation group.Another 106 patients without cerebrovascular disease were selected as the control group.Serum EPO index,blood routine index and blood rheology index were measured in the two groups.Spearman correlation analysis was used to compare the correlation between different indexes and blood EPO in the two groups.Results The serum EPO,plasma viscosity,erythrocyte sedimentation rate,whole blood high-viscosity,and whole blood low-cut viscosity index in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of red blood cell count,hematocrit and hemoglobin in the observation group were lower than those in the control group,such as red blood cell count,hematocrit and hemoglobin,and the differences were statistically significant(P<0.05).Correlation analysis showed that plasma viscosity,erythrocyte sedimentation rate,whole blood high-viscosity,whole blood low-cut viscosity,red blood cell count,hematocrit,hemoglobin and blood glucose EPO in the control group had no correlations(P>0.05).Plasma viscosity and erythrocyte sedimentation rate in the observation group positively correlated with EPO(r=0.347,0.431,P<0.05).Red blood cell count,hematocrit and hemoglobin in the observation group negatively correlated with EPO(r=-0.218,-0.543,-0.546,P<0.05).Conclusion There are some abnormalities in blood EPO,blood routine,and hemorheology in patients with ischemic stroke compared with those without ischemic stroke.Multiple blood routine and hemorheology indicators have correlation with serum EPO level in patients with ischemic stroke.Clinicians could further analyze the clinical characteristics of patients based on the correlation between serum EPO and hemorheology indicator

关 键 词：缺血性脑卒中 血清促红细胞生成素 血液流变学 相关性 

分 类 号：R743.9[医药卫生—神经病学与精神病学]