营养状况对肝癌根治术后患者化疗耐受与焦虑抑郁的影响  

Effect of nutritional status on chemotherapy tolerance and anxiety and depression in patients with liver cancer after radical operation

作　　者：魏红亚[1] WEI Hongya(Department of Gastroenterology,People′s Hospital of Hanzhong,Hanzhong,Shaanxi 723000,China)

机构地区：[1]陕西省汉中市人民医院消化内科,陕西汉中723000

出　　处：《检验医学与临床》2020年第17期2514-2516,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨营养状况对肝癌根治术后患者化疗耐受与焦虑抑郁的影响。方法将2017年9月至2019年9月该院收治的92例肝癌根治术后行辅助化疗的患者分为无营养不良组(42例)和营养不良组(50例)。患者的营养状况、焦虑及抑郁状况通过营养风险筛查量表2002(NRS2002)、焦虑自评量表(SAS)和抑郁自评量表(SDS)判断。结果化疗期间,营养不良组出现食欲减退、恶心呕吐及白细胞、血小板、红细胞计数减少的比例均明显高于无营养不良组,差异有统计学意义(P<0.05)。营养不良组产生焦虑和产生抑郁情绪比例均明显高于无营养不良组,差异有统计学意义(P<0.05)。无营养不良组治疗中断的比例明显低于营养不良组,差异有统计学意义(P<0.05)。结论营养不良会使肝癌根治术后患者的化疗耐受性降低,且增加患者焦虑抑郁发生的风险。Objective To explore the effect of nutritional status on chemotherapy tolerance and anxiety and depression in patients with liver cancer after radical operation.Methods A total of 92 patients who received adjuvant chemotherapy after radical resection of liver cancer from September 2017 to September 2019 in the hospital were enrolled in the study.According to the nutritional status before chemotherapy,92 patients were divided into non malnutrition group(42 cases)and malnutrition group(50 cases).The nutritional status,anxiety and depression status were assessed by nutritional risk screening scale 2002(NRS2002),Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS).Results During the chemotherapy,the incidence rates of anorexia,nausea and vomiting,decrease of count of leucopenia,thrombocytopenia and red blood cell in malnutrition group were significantly higher than those in non malnutrition group,and the differences were statistically significant(P<0.05).The incidence rates of anxiety and depression were higher than those in non malnutrition group,and the differences were statistically significant(P<0.05).The probability of treatment interruption in the non malnutrition group was lower than that in the malnutrition group,and the difference was statistically significant(P<0.05).Conclusion Malnutrition can reduce chemotherapy tolerance and increase the risk of anxiety and depression in patients with liver cancer after radical operation.

关 键 词：营养状况 肝癌根治术 化疗耐受 焦虑抑郁 

分 类 号：R735.7[医药卫生—肿瘤]