铁死亡及其在器官缺血再灌注损伤中作用研究进展  

Advances of ferroptosis in organ ischemia-reperfusion injury

作　　者：国胜文 童媛媛 柏利婷 靳雨 张沛瑶 李艺宣 段欣[1] 刘晋萍[1] Guo Shengwen;Tong Yuanyuan;Bai Liting;Jin Yu;Zhang Peiyao;Li Yixuan;Duan Xin;Liu Jinping(Department of Cardiopulmonary Bypass,State Key Laboratory of Cardiovascular Diseases,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院体外循环中心,北京100037

出　　处：《中国体外循环杂志》2020年第4期248-250,共3页Chinese Journal of Extracorporeal Circulation

基　　金：国家自然科学基金资助项目(81670375)。

摘　　要：铁死亡是近年来新发现的一种细胞死亡方式。本文概述铁死亡概念、形态生化特征、调控机制,以及铁死亡在在心肌、脑、肾、肝、肠道缺血再灌注损伤中作用机制和铁死亡治疗策略,旨在为体外循环器官保护提供理论基础。Ferroptosis is a new found pathway in cell death.This article demonstrates the concept,morphological and biochemical characteristics,regulatory mechanisms of ferroptosis,as well as the mechanism of ferroptosis in myocardial,brain,kidney,liver,and intestinal ischemia-reperfusion injury and the preventive strategies.The aim of this article is to provide new theoretical basis for organ protection associated with cardiopulmonary bypass surgery.

关 键 词：铁死亡 铁 体外循环 缺血再灌注损伤 脏器保护 

分 类 号：R364.1[医药卫生—病理学]