缺氧诱导因子在肺缺血-再灌注损伤中的研究进展  

Research advances in hypoxia-inducible factor in lung ischemia-reperfusion injury

作　　者：袁嘉喆(综述) 夏清平 邓丽(审校)[1] Yuan Jiazhe;Xia Qingping;Deng Li(Department of Cardiac Surgery,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院心外科,哈尔滨150001

出　　处：《中国体外循环杂志》2020年第4期251-256,共6页Chinese Journal of Extracorporeal Circulation

基　　金：国家自然科学基金青年科学基金项目(81900369)。

摘　　要：肺缺血-再灌注损伤(LIRI)是体外循环术后常见并发症,严重影响患者术后康复。目前对于其机制的探索还未完全认清。缺氧诱导因子(HIF)是一种在细胞缺氧状态下发挥调控功能的因子,随着近年来其研究的深入,HIF与缺血缺氧性疾病的关系也逐渐被证实。文献研究显示HIF在氧化应激、炎症、糖酵解以及细胞自噬等复杂机制中起着重要的调控作用,也有学者认为HIF是LIRI进程中的重要环节之一。因此,本文就HIF与LIRI的发生、发展关系研究进展作一综述。Lung ischemia-reperfusion injury(LIRI)is a common complication after extracorporeal circulation,which seriously affects postoperative recovery of patients.At present,the exploration of its mechanism has not been fully completed.Hypoxia-inducible factor(HIF)plays a regulatory role in the hypoxia state of cells.In recent years,the relationship between HIF and hypoxic-ischemic diseases has been gradually confirmed.Literature studies have shown that HIF plays an important regulatory role in complex mechanisms such as oxidative stress,inflammation,glycolysis and autophagy,and some scholars believe that HIF is one of the important segments in the process of LIRI.This article reviews the research progress on the occurrence and development of HIF and LIRI.

关 键 词：缺氧诱导因子 肺缺血-再灌注损伤 体外循环 心血管外科 

分 类 号：R73[医药卫生—肿瘤]