肝原发性腺鳞癌6例临床与病理学观察  

Clinicopathological manifestation of primary liver adenosquamous carcinoma:An analysis of six cases

作　　者：刘旭[1] 胡余昌[1] 陈路[1] 刘宇飞[1] 吴琪[1] Liu Xu;Hu Yuchang;Cheng Lu(Institute of Pathology,Sanxia University,Yichang 443001,Hubei Province,China)

机构地区：[1]三峡大学病理学研究所/宜昌市中心人民医院病理科,湖北省宜昌市443001

出　　处：《实用肝脏病杂志》2020年第5期727-730,共4页Journal of Practical Hepatology

基　　金：湖北省重点实验室开放基金资助项目(编号:2018KZL03);湖北省高等学校省级教学研究项目(编号:2017260)。

摘　　要：目的分析肝原发性腺鳞癌(ASC)患者临床和组织病理学特征。方法回顾性分析6例肝ASC患者的临床资料,采取肝叶切除或/和经动脉化疗栓塞治疗,采用SP法检测蛋白表达。结果在6例患者中,男性2例,女性4例;年龄为54~75岁,平均年龄为(63.0±8.3)岁;临床均以腹痛为首发表现,影像学检查发现肝内占位性病变;肿瘤组织肉眼观呈灰白色、实性,边界较清晰;镜下见瘤细胞呈巢状或腺管状;6例肝组织腺癌区域均表达CK7、CK19、cam5.2和Ki-67,4例表达CEA,3例表达CK20,2例表达CDX-2,1例表达MUC-1;鳞癌区域均表达p40、p63和CK5/6,4例弱阳性表达CK19,3例弱阳性表达EMA;术后平均生存6个月。结论肝原发性腺鳞癌主要依靠病理学检查诊断,其恶性程度较高,患者生存期短。Objective The aim of this study was to analyze the clinicopathological features of patients with primary adenosquamous carcinoma(ASC)of liver.Methods The clinical and histopathological data of 6 patients with ASC were analyzed retrospectively,and all patients received hepatectomy and/or TACE.The hepatic tissue protein expression was detected by SP.Results In the six patients,two were women and four women,aged 54-75 yr with an average age of(63.0±8.3)yr;all patients presented with abdominal pain and intrahepatic foci were found by imaging examination;the gross foci mass was grayish white and solid with a relative clear border;the tumor cells were nested or glandular tubular microscopically;the SP detection showed the hepatic CK7,CK19,cam5.2 and Ki-67 positive in six,CEA positive in four,CK20 in three,CDX-2 in two and MUC-1 in one;the overall survival was 6 months.Conclusion The diagnosis of primary ASC of liver depends on the pathological examination,the tumor is malignant and the survival of patients is short.

关 键 词：肝腺鳞癌 组织病理学 蛋白表达 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]