“4+7城市”药品集中采购实施后广东省第二人民医院原研药与仿制药使用情况分析  

Analysis of Application of Original Drugs and Generic Drugs after the Implementation of“4+7 Cities”Group Procurement of Drugs in Guangdong Second Provincial Central Hospital

作　　者：邹国盛[1] 赵家强 梅清华[1] 叶浩婷 周辉[1] 朱新昌[1] 李素娟 ZOU Guosheng;ZHAO Jiaqiang;MEI Qinghua;YE Haoting;ZHOU Hui;ZHU Xinchang;LI Sujuan(Dept. of Pharmacy, Guangdong Second Provincial General Hospital,Guangdong Guangzhou 510317, China)

机构地区：[1]广东省第二人民医院药学部,广东广州510317

出　　处：《中国医院用药评价与分析》2020年第7期854-858,共5页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:以心血管科、神经内科、肝病科药品为例,了解原研药与仿制药在“4+7城市”药品集中采购实施后的使用情况,为促进仿制药的使用提供数据支持。方法:选取2019年4—9月广东省第二人民医院(以下简称“我院”)原研药及仿制药的使用数据,数据采集通过我院药品信息管理系统进行,选择10种心血管系统用药、抗抑郁药、抗精神病药及抗病毒药,对原研药与仿制药的价格比、销售金额、仿制药替代原研药潜在节省费用以及使用数量等情况进行比较,其中价格经标化后为采购价的标准单位(DDDc);同时,比较原制药和仿制药的处方量、使用人次以及不良反应发生情况。结果:2019年4—9月,我院原研药平均使用数量占比为23.67%(50190盒/212005盒),仿制药平均使用数量占比为76.33%(161815盒/212005盒);原研药平均销售金额占比为51.57%(2563302.29元/4970824.95元),仿制药为48.43%(2407522.66元/4970824.95元);原研药中,使用数量占比最大的药品为厄贝沙坦氢氯噻嗪片(12290盒,占24.49%),销售金额占比最大的药品为硫酸氢氯吡格雷片(999988.50元,占39.01%);仿制药中,使用数量占比最大的药品为阿托伐他汀钙片(61524盒,占38.02%),销售金额占比最大的药品为硫酸氢氯吡格雷片(1149306.06元,占47.74%);10种原研药药品价格DDDc平均值为13.71;仿制药药品价格DDDc平均值为2.95;仿制药替代原研药的潜在节省费用合计1686199.20元,费用节省率为65.78%;奥氮平原研药价格DDDc值为70.57,而仿制药价格DDDc值为11.06。仿制药的处方量和原研药基本一致,且使用人次明显多于原研药。仿制药与原研药的不良反应发生率相近。结论:“4+7城市”药品集中采购实施后,我院10种仿制药的使用量和销售金额有所升高,仿制药替代原研药的费用节省率较高,可节约大量药品费用。此外,仿制药不会增加处方量以及不良反应发生风险,更易被患者所接OBJECTIVE:Taking cardiovascular and internal medicine-neurology drugs of our hospital as an example,to investigate the application of original drugs and generic drugs after the implementation of“4+7 Cities”group procurement of drugs,so as to provide data support for promoting the application of generic drugs.METHODS:The application data of the original drugs and generic drugs in Guangdong Second Provincial General Hospital(hereinafter referred to as“our hospital”)from Apr.to Sept.2019 were extracted through the drug information management system.A total of 10 kinds of cardiovascular drugs,antidepressants,antipsychotics and antiviral drug were selected to compare the price ratio of original drugs to generic drugs,the consumption sum,the potential cost savings of replacing the original drugs,and the consumption amount.The standard unit of the purchase price(DDDc)was standardized.In addition,the quantity of prescriptions,the number of users and the incidence of adverse drug reactions of original and generic drugs were compared.RESULTS:From Apr.to Sept.2019,the average amount of original drugs used in our hospital was 23.67%(50190/212005),and that of the generic drugs was 76.33%(161815/212005).The average consumption sum of the original drug was 51.57%(2563302.29 yuan/4970824.95 yuan),and that of the generic drug was 48.43%(2407522.66 yuan/4970824.95 yuan).Among the original drugs,Irbesartan hydrochlorothiazide tablets(12290,24.49%)took the largest proportion of consumption amount,and Clopidogrel bisulfate tablets(999988.50 yuan,39.01%)took the largest proportion of consumption sum.Among the generic drugs,Atorvastatin calcium tablets(61524,38.02%)took the largest proportion of consumption amount,and Clopidogrel bisulfate tablets(1149306.06 yuan,47.74%)took the largest proportion of consumption sum.The average value of DDDc of 10 original drugs was 13.71,while that of generic drugs was 2.95.The total potential cost savings of generic drugs replacing the original drugs was 1686199.20 yuan,the cost saving rate w

关 键 词：原研药 仿制药 “4+7城市”药品集中采购 价格比 药物使用情况 

分 类 号：R97[医药卫生—药品]