乌灵胶囊联合腹针治疗脑卒中后疲劳的疗效分析  

Therapeutic effect of Wuling capsule combined with abdominal acupuncture on post-stroke fatigue

作　　者：郑双双[1] 钟根龙 黎普刚[1] 王法明[1] 张婷[1] 毛平安[1] ZHENG Shuangshuang;ZHONG Genlong;LI Pugang;WANG Faming;ZHANG Ting;MAO Ping'an(Department of Rehabilitation,Lishui City People's Hospital in Zhejiang Province,Lishui 323000,China)

机构地区：[1]浙江省丽水市人民医院康复医学科,浙江丽水323000

出　　处：《中国现代医生》2020年第21期106-109,共4页China Modern Doctor

基　　金：浙江省基础公益研究计划项目(LGF19H090005);浙江省丽水市科技计划项目(2015sjzc22)。

摘　　要：目的研究乌灵胶囊联合腹针治疗脑卒中后疲劳的疗效,并探讨脑卒中后疲劳炎症因子变化及可能作用机制。方法选择2016年1月~2017年9月浙江省丽水市人民医院住院的90例脑卒中后疲劳患者,将其随机分为对照组、治疗组,每组45例。对照组为基础治疗+常规康复训练,治疗组在对照组基础上加用乌灵胶囊联合腹针治疗。比较两组治疗前及治疗后12周的疲劳严重程度量表(FSS)、脑卒中生活质量量表(SSQOL-E)评分变化,并监测血清白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)浓度变化。结果经治疗后,两组FSS评分及血清IL-6、IL-1β、TNF-α浓度均下降,SSQOL-E评分较前升高,差异有统计学意义(P<0.05),且血清IL-6、IL-1β、TNF-α浓度变化与FSS评分均呈正相关,与SSQOL-E评分呈负相关。经治疗后,治疗组的FSS评分与对照组比较下降更明显,差异有统计学意义(P<0.05),治疗组SSQOL-E评分与对照组比较升高更明显,差异有统计学意义(P<0.05)。结论乌灵胶囊联合腹针治疗能够改善脑卒中后疲劳患者的疲劳程度,其机制可能与降低血清炎症因子的浓度有关。Objective To study the efficacy of Wuling capsule combined with abdominal acupuncture in the treatment of post-stroke fatigue,and to explore the changes of fatigue inflammatory factors and possible mechanisms of action after stroke.Methods 90 patients with post-stroke fatigue who were admitted to the Department of Rehabilitation and Neurology of Lishui City People's Hospital from January 2016 to September 2017 were randomly divided into the control group and the treatment group,with 45 cases in each group.The control group was treated with basic therapy+routine rehabilitation training.The treatment group was treated with Wuling capsule combined with abdominal acupuncture on the basis of the treatment of the control group.The changes in the fatigue severity scale(FSS)and stroke specific quality of life scale evaluation(SSQOL-E)scores before and after treatment(12 weeks)were compared between the two groups.The changes in the concentration of the serum interleukin-6(IL-6)and leukocytes interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were monitored.Results After treatment,the FSS scores and serum IL-6,IL-1β,TNF-αconcentrations decreased,and SSXOL-E scores increased,with statistically significant difference(P<0.05).The changes in concentrations of serum IL-6,IL-1βand TNF-αwere positively correlated with FSS scores and negatively correlated with SSQOL-E scores.After treatment,the FSS score of the treatment group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The SSQOL-E score of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Wuling capsule combined with abdominal acupuncture can improve the fatigue of patients after stroke,and its mechanism may be related to the decrease of serum inflammatory factor concentration.

关 键 词：卒中后疲劳 乌灵胶囊 腹针治疗 康复训练 血清致炎因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]