膀胱尿路上皮细胞癌患者外周血NLR,PLR,MLR和RDW水平表达及在临床分期评估中的价值  

Expression of NLR,PLR,MLR and RDW in Serum of Bladder Urothelial Cell Carcinoma and Its Value in Clinical Staging

作　　者：李卿英 LI Qing-ying(Department of Urology,the Third Hospital of Xi'an,Xi’an 710082,China)

机构地区：[1]西安市第三医院泌尿外科,西安710082

出　　处：《现代检验医学杂志》2020年第4期89-93,共5页Journal of Modern Laboratory Medicine

摘　　要：目的观察膀胱尿路上皮细胞癌外周血中性粒细胞计数/淋巴细胞计数比率(NLR),血小板计数/淋巴细胞计数比率(PLR),单核细胞计数/淋巴细胞计数比率(MLR)和红细胞体积分布宽度(RDW)表达情况,并分析其在临床分期评估中的价值。方法回顾性分析118例膀胱尿路上皮细胞癌病例资料,所有病例均于治疗前清晨空腹采血行NLR,PLR,MLR和RDW水平表达检测,观察不同临床分期患者外周血NLR,PLR,MLR和RDW水平表达差异及相关性,采用ROC曲线法分析外周血NLR,PLR,MLR和RDW在膀胱尿路上皮细胞癌临床分期评估中的效能。结果患者外周血NLR,PLR和RDW表达水平随临床分期的提升而提升,外周血MLR表达水平下降,且不同临床分期(TⅠ期、TⅡ期、TⅢ期和TⅣ期)病例的外周血NLR,PLR,MLR和RDW表达比较差异具有统计学意义(F=31.152~56.182,均P<0.05)。Spearman秩相关性分析显示:外周血NLR(r=0.813,P=0.016),PLR(r=0.881,P=0.013)和RDW(r=0.857,P=0.014)与临床分期呈正相关(P<0.05);外周血NLR(r=-0.583,P=0.014)与临床分期呈负相关(P<0.05)。ROC曲线数据显示:外周血NLR,PLR,MLR和RDW表达水平鉴别临床分期的曲线位于参考线之上,且外周血NLR,PLR,MLR和RDW在鉴别TⅠ期与TⅡ期、TⅡ期与TⅢ期、TⅢ期与TⅣ期的准确度、敏感度和特异度均高于80%。结论外周血NLR,PLR,MLR和RDW与膀胱尿路上皮细胞癌临床分期具有相关性,其在鉴别膀胱尿路上皮细胞癌临床分期中具有一定的临床价值。Objective To observe the expression of NLR,PLR,MLR and RDW in peripheral blood of bladder urothelial carcinoma and analyze its value in clinical stage evaluation.Methods 118 cases of bladder urothelial cell carcinoma were analyzed retrospectively.All the patients were taken fasting blood in the early morning before treatment and the expression of NLR,PLR,MLR and RDW were detected.Observed the expression difference and correlation of NLR,PLR,MLR and RDW in peripheral blood of patients with different clinical stages,and analyzed the efficacy of NLR,PLR,MLR and RDW in clinical stage evaluation of bladder urothelial cell carcinoma by ROC curve method.Results Patients with peripheral blood NLR,PLR and RDW expression level along with the ascension of clinical staging,peripheral blood MLR expression level decreased,and different clinical stagesⅠ(TⅠstage,TⅡstage,TⅢstage,TⅣstage)cases of peripheral blood NLR,PLR,MLR and RDW expression was statistically significant(F=31.152~56.182,all P<0.05).Spearman rank correlation analysis showed that peripheral blood NLR(r=0.813,P=0.016),PLR(r=0.881,P=0.013)and RDW(r=0.857,P=0.014)were positively correlated with clinical staging(P<0.05).Peripheral blood NLR(r=-0.583,P=0.014)was negatively correlated with clinical staging(P<0.05).ROC curve data showed that:peripheral blood NLR,PLR,MLR and RDW expression level curve was above reference line and identify the clinical stages and peripheral blood NLR,PLR,MLR and RDW TⅠstage with TⅡstagein identification,TⅢstage TⅣstage accuracy,sensitivity,specific degree were higher than 80%.Conclusion Peripheral blood NLR,PLR,MLR and RDW were correlated with the clinical stage of urothelial carcinoma of the bladder,and have certain clinical value in distinguishing the clinical stage of urothelial carcinoma of the bladder.

关 键 词：膀胱尿路 上皮细胞癌 中性粒细胞计数/淋巴细胞计数比率 血小板计数/淋巴细胞计数比率 单核细胞计数/淋巴细胞计数比率 红细胞体积分布宽度 分期评估 价值 

分 类 号：R737.14[医药卫生—肿瘤] R730.43[医药卫生—临床医学]