两种新型苯甲酰腙配合物的合成及其结构和抑菌活性研究  

Synthesis and antibacterial activities of two novel holmium(Ⅲ)and dysprosium(Ⅲ)complexes with benzoyl hydrazone ligand

作　　者：高霞 乔成芳 刘永亮 周春生 张国春 GAO Xia;QIAO Chengfang;LIU Yongliang;ZHOU Chunsheng;ZHANG Guochun(Shaanxi Key Laboratory of Comprehensive Utilization of Tailings Resources,Department of Chemical Engineering and Modern Materials,Shangluo University,Shangluo 726000,Shaanxi,China;Laboratory of Macromolecular Science of Shaanxi Province,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi′an 710119,Shaanxi,China)

机构地区：[1]商洛学院化学工程与现代材料学院,陕西省尾矿资源综合利用重点实验室,陕西商洛726000 [2]陕西师范大学化学化工学院,陕西省大分子科学重点实验室,陕西西安710119

出　　处：《陕西师范大学学报（自然科学版）》2020年第5期11-18,共8页Journal of Shaanxi Normal University：Natural Science Edition

基　　金：国家自然科学基金(201703135);商洛学院科研基金(19SKY003)。

摘　　要：在无水乙醇中以丙酮酸和3-甲氧基苯甲酰肼为原料,通过缩合反应合成丙酮酸-3-甲氧基苯甲酰腙(PMBH)。以自制PMBH为配体,使用传统溶液法在水-乙醇混合溶剂中分别与稀土金属离子Ho^3+和Dy^3+自组装,得到两种结构新颖的配合物:[Ho(PMBH)3][Ho′(PMBH)3](1,Ho(Ⅲ))和[Dy(PMBH)3][Dy′(PMBH)3]·2CH3OH·H2O(2,Dy(Ⅲ))。采用元素分析、X-射线粉末衍射、X-射线单晶衍射、红外光谱、热重分析等手段对配合物1和2的结构和性质进行表征,采用菌落直径法研究了配合物1和2及其自由配体PMBH对腐皮镰刀真菌的抑菌活性。结果表明,配体PMBH及其配合物1和2对腐皮镰刀真菌的生长都具有抑制作用,且配合物1和2对腐皮镰刀真菌的抑制作用较配体PMBH更强。A novel hydrazone ligand pyruvate-3-methoxy benzoyl hydrazone(PMBH)has been synthesized from pyruvic acid and 3-methoxybenzhydrazide in anhydrous alcohol.The conventional solution reaction of PMBH with rare earth ions(RE 3+=Ho 3+and Dy 3+)in water-ethanol solvent was carried out to generate two novel complexes:[Ho(PMBH)3][Ho′(PMBH)3](1)and[Dy(PMBH)3][Dy′(PMBH)3]·2CH 3 OH·H 2 O(2).The structures and properties of the two complexes were investigated by means of elemental analysis,X-ray powder diffraction(XRPD),X-ray single-crystal diffraction,fourier-transform infrared spectroscopy(FT-IR)and thermogravimetric analysis(TGA).The antibacterial activities of PMBH ligand and its complex 1 and 2 against Fusarium solani were investigated by colony diameter method.The results showed that they all demonstrated antibacterial activities against Fusarium solani,and complex 1 and 2 have much stronger antibacterial activities than that of the PMBH ligand.

关 键 词：Ho(Ⅲ) Dy(Ⅲ) 配合物 丙酮酸-3-甲氧基苯甲酰腙 抑菌活性 

分 类 号：O614[理学—无机化学]