从红树林内生真菌Penicillium sp.SCNU-F0003中分到的1个新的tetronic acid二聚体  

One new tetronic acid dimer from a mangrove endophytic fungus Penicillium sp.SCNU-F0003

作　　者：郭惠娴 黄翠莹 颜樟元 陈涛[1] 李婉莹 龙玉华[1] GUO Hui-xian;HUANG Cui-ying;YAN Zhang-yuan;CHEN Tao;LI Wan-ying;LONG Yu-hua(Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine,School of Chemistry,South China Normal University,Guangzhou 510006,China)

机构地区：[1]华南师范大学广州生物医学分析化学重点实验室,化学学院,广东广州510006

出　　处：《中国海洋药物》2020年第4期1-6,共6页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(41876153,41376149);广东省自然科学基金项目(2017A030313088)资助。

摘　　要：目的评价从红树林内生真菌Penicillium sp.SCNU-F0003中分离得到的新化合物(+)-(5R,5’R)-3,3’-methylenebistetronic acid(1)和5个已知化合物的潜在活性。方法通过核磁数据分析和单晶衍射分析确定化合物1的绝对构型,并测定所有化合物的抗氧化活性和α-葡萄糖苷酶抑制活性。结果化合物1显示中等抗氧化活性,IC50值为81.6μmol/L,化合物2(IC50=270.3μmol/L)显示出α-葡萄糖苷酶抑制活性,比阳性药物阿卡波糖(IC50=725.1μmol/L)活性更好。结论化合物1和2具有潜在的生物活性。Objective To evaluate potential activity of the new tetronic acid dimer,(+)-(5 R,5’R)-3,3’-methylenebistetronic acid(1),isolated from an endophytic fungus Penicillium sp.SCNU-F0003,along with five known compounds.Methods The structure including absolute configuration of 1 was elucidated by extensive spectroscopic data and X-ray diffraction analysis.The antioxidant activity andα-glucosidase inhibitory activity were assayed for all the isolated compounds.Results Compound 1 exhibited moderate antioxidant activity with an IC50 value of 81.6μmol/L and compound 2 showed more potentialα-glucosidase inhibitory activity(IC50=270.3μmol/L)than the positive control acarbose(IC50=725.1μmol/L).Conclusion Compounds 1 and 2 had potential biological activities.

关 键 词：tetronic acid 抗氧化活性 α-葡萄糖苷酶抑制活性 红树林真菌 次级代谢产物 

分 类 号：R931.77[医药卫生—生药学]