精神分裂症不同临床阶段患者社会认知加工的眼动特征  

Eye movement characteristics of social cognitive processing in patients with schizophrenia across different clinical stages

作　　者：朱怡康[1] 徐丽华[1] 苏文君 郭茜[1] 李瑜[1] 王燕 张天宏[1] 王继军[1,2,3,4] 李春波 Zhu Yikang;Xu Lihua;Su Wenjun;Guo Qian;Li Yu;Wang Yan;Zhang Tianhong;Wang Jijun;Li Chunbo(Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Institute of Psychology and Behavioral Science,Shanghai Jiao Tong University,Shanghai 200030,China;Institute of Brain Science and Technology,Shanghai Jiao Tong University,Shanghai 200030,China;CAS Center for Excellence in Brain Science and Intelligence Technology,Shanghai 200031,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心上海市重性精神病重点实验室,200030 [2]上海交通大学心理与行为科学研究院,200030 [3]上海交通大学脑科学与技术研究中心,200030 [4]中国科学院脑科学与智能技术卓越创新中心,上海200031

出　　处：《中华行为医学与脑科学杂志》2020年第8期730-735,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目(81671329);上海市卫健委青年项目(20144Y0053);上海交大医学院转化医学青年项目(ZH2018QNB19);上海市精神卫生中心"飞翔计划"人才项目(2018-FX-04)。

摘　　要：目的探讨不同临床阶段的精神分裂症患者社会认知加工的眼动特征及其与临床症状之间的关系。方法对15例首发精神分裂症患者(首发组)、46例慢性住院精神分裂症患者(慢性组)、36例精神病临床高危综合征患者(临床高危组)和26例健康对照组采用眼动追踪技术记录四组被试对人际互动图片的眼动轨迹。采用SPSS 17.0进行协方差分析和偏相关分析。结果在观看人物交流图片时,四组被试的注视时长分别为:对照组(294.6±36.7)ms,临床高危组(280.0±54.0)ms,首发组(268.5±34.9)ms,慢性组(315.7±75.7)ms,差异有统计学意义(F=3.18,P=0.027)。观看无人风景图时,四组被试的平均跳视幅度分别为:对照组(5.3±1.1)°,临床高危组(4.7±1.1)°,首发组(5.2±1.0)°,慢性组(4.4±1.2)°,差异有统计学意义(F=3.37,P=0.021)。慢性组患者在观察人物交流图片、人物无交流图片和无人物风景图片时的注视时长均与PANSS总分成正相关(偏相关系数=0.313,P=0.039;偏相关系数=0.320,P=0.034,偏相关系数=0.372,P=0.013)。慢性组患者在观察无人物风景图片时平均注视时长与PANSS阳性症状评分成正相关(偏相关系数=0.321,P=0.034)。慢性组患者在观察任意一类图片平均注视时长与PANSS一般症状评分成正相关(人物交流图片:偏相关系数=0.385,P=0.010;人物无交流图片:偏相关系数=0.409,P=0.006;无人物风景图:偏相关系数=0.465,P=0.001)。首发组患者在观察人物无交流图片时的跳视幅度与PANSS阳性症状评分成正相关(偏相关系数=0.555,P=0.049)。临床高危组患者在观察人物交流图片时的平均跳视幅度与SOPS阳性症状评分成负相关(偏相关系数=-0.373,P=0.030)。结论精神分裂症不同临床阶段患者社会认知加工的眼动特征具有明显差异。与平均注视时长相比,跳视幅度对于临床高危期患者症状严重程度的预测更灵敏。Objective To explore the eye movement characteristics of social cognitive processing in schizophrenia patients across different stages and its association with clinical symptoms.Methods Fifteen patients with first-episode schizophrenia,forty-six patients with chronic inpatient schizophrenia,thirty-six patients with psychiatric clinical high-risk syndrome,and twenty-six healthy controls were recorded using eye tracking technology when viewing social interaction pictures.Covariance analysis and partial correlation analysis were conducted by SPSS17.0.Results When watching the pictures of person communication,there were statistically significant differences in the average fixation duration of the four groups of subjects((294.6±36.7)ms in control group,(280.0±54.0)ms in clinical high-risk group,(268.5±34.9)ms in first-episode group,and(315.7±75.7)ms in chronic group,respectively,F=3.18,P=0.027).When viewing the pictures of no person landscape,the average saccade amplitude of the four groups of subjects was significantly different(5.3±1.1)°in control group,(4.7±1.1)°in clinical high-risk group,(5.2±1.0)°in first-episode group,and(4.4±1.2)°in chronic group,respectively,F=3.37,P=0.021).The average fixation duration of chronic patients when observing person communication pictures was positively correlated with the total score of PANSS(partial correlation coefficient=0.313,P=0.039).The average fixation duration of chronic patients when observing the other two types of pictures were also positively correlated with the total score of PANSS(partial correlation coefficient=0.320,P=0.034,no person communication pictures;partial correlation coefficient=0.372,P=0.013,no person landscape pictures).The average fixation duration of chronic patients when observing pictures of no person landscape was positively correlated with the PANSS positive symptom score(partial correlation coefficient=0.321,P=0.034).The average fixation duration of chronic patients when observing any type of picture was positively correlated with the

关 键 词：精神分裂症 社会认知加工 眼动特征 

分 类 号：R749.3[医药卫生—神经病学与精神病学]