Effects of Electroacupuncture on Pain Threshold and Prostaglandin E2 in Spinal Cord in Postoperative Pain Rat  

作　　者：WANG Jin-kun YU Xue CAO Kang-di YE Chen CHEN Yu-qi LIU Huai-wei XUE Na-ying XI Meng-qi REN Xiu-jun 王瑾琨;于雪;曹康迪;叶晨;陈宇琦;刘怀伟;薛娜英;係梦琪;任秀君(School of Acupunture-Moxibusion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]School of Acupunture-Moxibusion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China [2]School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China

出　　处：《World Journal of Integrated Traditional and Western Medicine》2020年第4期35-41,共7页世界中西医结合杂志（英文）

基　　金：supported by a grant from National University Students'Innovation and Entrepreneurship Training project(No.201810026036);a grant from the National Key Basic Research and Development Program"973"Project(No.2007CB512503)。

摘　　要：Objective:Electroacupuncture(EA)is good at post-surgical pain.But point selection method in treating incision-induced pain remains a major clinical challenge.We reasoned that different acupoints may work though adjusting prostaglandin E2 in spinal cord.We wish to explore the analgesic mechanism of electroacupuncture on plantar incision pain rats and provide more therapeutic ideas for acupuncture analgesia.Methods:A total of 50 male rats were randomly divided into a sham operation group,a model group,an EA 1,EA 2 and a drug group(n=10,each).A rat model of left plantar incision pain was established.The rats in EA1 group was needled at ipsilateral Yanglingquan(GB34)and Taixi(KI3).The rats in EA2 group was needled at ipsilateral Quchi(LI11)and Hegu(LI4).EA stimulation(2/100 Hz,1-2-3 mA)was administered 30 minutes immediately after operation.The rats in drug group were fed with Fenbid by gavage 20 minutes before incision(30 mg/kg,p.o.).The hot plate pain detector was used to measure the thermal pain threshold(TPT)before and 24 hours after operation Prostaglandin E2 content of spinal cord was detected by enzyme-linked immunosorbent assay(ELISA)at 1 and 24 hours after operation.Results:Compared with sham operation group,the TPT in model group decreased 41%.Compared with the model group,the TPT increased 56%in EA1,29%in EA2,190%in drug group(P>0.05).At 1 h after operation,compared with the sham operation group,PGE_2 in model group increased 15%.Compared with the model group,PGE_2 in drug group decreased 5%.At 24 hours after operation,compared with sham operation group,PGE_2 in model group increased 9%.Compared with model group,it decreased 4%in EA 1 group,8%in drug group and increased 3%in EA2 group.Conclusion:Both the drug and the electroacupuncture can adjust the 24-hour pain threshold and PGE_2 in spinal cord.The curative effects of the drug are better than that of electroacupuncture.The proximal point is better than that of the distal point.Electroacupuncture can treat postoperative pain by regulating PGE_2 in spinal

关 键 词：ELECTROACUPUNCTURE Postoperative pain Pain threshold Spinal cord PROSTAGLANDIN 

分 类 号：R245[医药卫生—针灸推拿学]