血清载脂蛋白水平可能与额叶癫痫的癫痫控制状态相关  

Serum apolipoprotein levels is related to epilepsy control status in frontal lobe epilepsy

作　　者：马维宁[1] 赵旭阳 李春[3] 黎瀚[1] 孟季红[1] 刘丽萍 李少一[1] MA Wei-ning;ZHAO Xu-yang;LI Chun;LI Han;MENG Ji-hong;LIU Li-ping;LI Shao-yi(Department of Neurosurgery,Shengjing Hospital of China Medical University,Shenyang 110004;Department of Pathology,Peking University Health Science Center,Beijing 100191;Department of Pediatrics,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院神经外科,辽宁沈阳110004 [2]北京大学医学部基础医学院病理系,北京100191 [3]中国医科大学附属盛京医院小儿神经内科,辽宁沈阳110004

出　　处：《解剖科学进展》2020年第4期408-412,共5页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81573460)。

摘　　要：目的探索术后无癫痫发作的额叶癫痫患者术前和术后血清中是否存在蛋白表达的差异。方法利用蛋白质组学的方法对5例确诊为额叶癫痫的手术患者血清蛋白质组进行了定量分析,采用了自身前后对照的方法,选取术前和术后1年两个时间段的血清样本进行蛋白质组学的分析。结果在血清中发现了大约600种蛋白质,其中14种在术前和术后有统计学差异,13个蛋白包括3个载脂蛋白亚型(APOA2,APOC1和APOC2)在术前的表达水平较高,另外1个蛋白术前较术后表达水平降低。结论血清载脂蛋白表达水平可能与癫痫控制状态有关。Objective This study is designed to find out if there are some differential protein expressions in serum between pre-and post-operation of FLE patients. Methods We have utilized proteomic approaches to quantify the proteome of serum from 5 surgery patients who were diagnosed with FLE. The self-control method was used in the study, and serum samples from two time periods, including pre-operation and one year after the surgery were selected. Results We identified about six hundred proteins in serum, and 14 of them had statistical difference between pre-and postoperation. Thirteen proteins including 3 apolipoprotein subtypes(APOA2, APOC1, and APOC2) had higher expression levels with the other one had a lower expression level in the pre-operation group compared to the post-operation group. Conclusion Apolipoprotein expression levels in serum of FLE might related to epilepsy control state.

关 键 词：额叶癫痫 载脂蛋白 蛋白质组学 

分 类 号：R749.1[医药卫生—神经病学与精神病学]