N-myristoylation:from cell biology to translational medicine  

作　　者：Meng Yuan Zi-han Song Mei-dan Ying Hong Zhu Qiao-jun He Bo Yang Ji Cao 

机构地区：[1]Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China

出　　处：《Acta Pharmacologica Sinica》2020年第8期1005-1015,共11页中国药理学报（英文版）

基　　金：the National Natural Science Foundation of China(81872885 to J.C.);Zhejiang Provincial Natural Science Foundation(Y18H310005 to J.C.);the Talent Project of Zhejiang Association for Science and Technology(No.2018YCGC002 to J.C.).

摘　　要：Various lipids and lipid metabolites are bound to and modify the proteins in eukaryotic cells,which are known as'protein lipidation'.There are four major types of the protein lipidation,i.e.myristoylation,palmitoylation,prenylation,and glycosylphosphatidylinositol anchor.N-myristoylation refers to the attachment of 14-carbon fatty acid myristates to the N-terminal glycine of proteins by N-myristoyltransferases(NMT)and affects their physiology such as plasma targeting,subcellular tracking and localization,thereby influencing the function of proteins.With more novel pathogenic N-myristoylated proteins are identified,the N-myristoylation will attract great attentions in various human diseases including infectious diseases,parasitic diseases,and cancers.In this review,we summarize the current understanding of N-myristoylation in physiological processes and discuss the hitherto implication of crosstalk between N-myristoylation and other protein modification.Furthermore,we mention several well.studied NMT inhibitors mainly in infectious diseases and cancers and generalize the relation of NMT and cancer progression by browsing the clinic database.This review also aims to highlight the further investigation into the dynamic crosstalk of N-myristoylation in physiological processes as well as the potential application of protein N-myristoylation in translational medicine.

关 键 词：N-MYRISTOYLATION N-MYRISTOYLTRANSFERASE infectious diseases parasitic diseases cancers translational medicine 

分 类 号：R91[医药卫生—药学]