富血小板纤维蛋白在牙周组织再生中的研究进展  

Research Progress of PRF in Periodontal Regeneration

作　　者：孙涛[1] 和红兵[1] SUN Tao;HE Hongbing(Department of Periodontics, the Affiliated Hospital of Stomatology of Kunming Medical University, Kunming 650106, China)

机构地区：[1]昆明医科大学附属口腔医院牙周病科,昆明云南650106

出　　处：《口腔医学研究》2020年第9期808-810,共3页Journal of Oral Science Research

基　　金：国家自然科学基金(编号:81660184)。

摘　　要：牙周组织再生一直是牙周炎治疗的难点与热点。富血小板纤维蛋白(platelet-rich fibrin,PRF)是同时包含细胞、生长因子、纤维蛋白生物支架的第二代自体血小板血浆制品。近年来,由于低离心力概念引导的制备程序使PRF的理化性质发生了一些改变,形成了一些新的分支。PRF在生物信号分子、生物支架及血供方面贴近理想的组织再生微环境体系,能够促进再血管化和组织愈合,并能与药物及细胞联合应用以促进牙周组织再生的发生。本文将就近年来PRF在牙周组织再生领域的研究进行综述。Periodontal tissue regeneration is always a difficult and hot point in the treatment of periodontitis.PRF is a second-generation autologous platelet plasma product containing cells,growth factors,and fibrin biological scaffolds.In recent years,the physical and chemical properties of PRF have changed due to LSCC guided preparation procedure,and some new branches have been formed.PRF is close to the ideal microenvironment system of tissue regeneration in terms of biological signaling molecules,biological scaffolds,and blood supply,which can promote the revascularization and tissue healing.PRF can be used in combination with drugs and cells to promote the occurrence of periodontal tissue regeneration.This paper will review the researches of PRF in periodontal tissue regeneration in recent years.

关 键 词：富血小板纤维蛋白 牙周再生 再血管化 

分 类 号：R78[医药卫生—口腔医学]